Markets And Surveys

Therapeutic Area

Technology

Product Name

Disease

Product Category

Patent Expiry

Profit Margin

Expected Growth in %

Market Size By Volume (MTS)

Product Name	Therapeutic Area	Disease	Product Category	No. of Buyers	Profit_margin	No. of Manufacturer	Technology	Patient Expiry	Expected Growth Percentage	Global Market Size by Volume (MTS)	Five Years Average Export (MTS)	Five Years Average Impo (MTS)
Histamine	Anti-allergic	Allergy	Biotech & Biochemicals	9	43%	6	--	--	7.1	0.2	0	0
Levometamphetamine	Anti-histamine	Nasal Congestion	Biotech & Biochemicals	1	24%	1	Acylation, deoxygenation, Hydrolysis	--	--	0	0	0
Paracetamol	Pain Management	Fever And Pain Of Perioperative Period In Multimodal Analgesia Therapy	Chemical Pharmaceuticals	803	75%	329	Friedel-Crafts Acylation, Imine Synthesis, N-Acetylation, Nitration, No-Reduction	2021	4.3	89937.7	13720.67	1888.35
Theophylline	Anti-asthmatic	Chronic Asthma, Lung Disease	Chemical Pharmaceuticals	10	661%	11	--	2001	5.2	818.7	1.48	0.14
Rilmenidine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	2	311%	1	Phosgenation	2032	7.2	0	0	0
L-Epinephrine	Anti-allergic	Allergic Reactions	Chemical Pharmaceuticals	58	39%	45	Resolution, Methylation	2025	8.3	494.5	0	0
Zofenopril	Anti-hypertensive	Hypertension, Kidney Disorder	Chemical Pharmaceuticals	47	47%	57	Diazomethane Technology, Hydrolysis	--	--	583.4	0	0
Phenazone	Pain Management	Pain & Fever	Chemical Pharmaceuticals	11	50%	16	Condensation, methyalation	--	6.5	53.4	6.83	6.32
Dihydralazine	Anti-hypertensive	Acute Or Chronic Vascular Hypertension	Chemical Pharmaceuticals	2	70%	--	Oxidative chlorination, hydrolysis	1979	2.1	0	0.15	0
Hydralazine Hydrochloride	Anti-hypertensive	Chronic Hypertension	Chemical Pharmaceuticals	46	577%	36	Bromination, Chlorination, Dehydroxy-Chlorination	2022	--	61.1	11.83	0.22
Tetrahydrozoline	Pain Management	Discomfort And Redness Of The Eye Due To Minor Eye Irritations	Biotech & Biochemicals	2	39%	2	Tetrahydrobiopterin synthesis, purification, recrystallization	1975	--	0	0	0
Chlorphenesin	Pain Management	Injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia	Chemical Pharmaceuticals	120	228%	39	Transesterification	--	8.9	1965.2	339.32	1.48
Mecamylamine Hyrochloride	Anti-hypertensive	Hypertension	Biotech & Biochemicals	1	71%	1	Ritter reaction	--	--	--	0	0
Dexibuprofen	Anti-Gout	Back Pain, Dysmenorrhoea, Headache, Inflammation, Musculoskeletal Pain, Osteoarthritis, Pain, Postoperative Pain, Rheumatic Disorder	Chemical Pharmaceuticals	212	642%	142	3 ketone carbonyl-protection reactions, 17 hydroxyl protection reactions, grignard reaction, 3 reactions of ketone carbonyl deprotection, dehydration reaction and dehydrogenation reactions	2012	12.6	245.1	1.58	5.63
Ibuprofen	Anti-Gout	Moderate Pain Related To Dysmenorrhea, Headache, Migraine, Postoperative Dental Pain, Spondylitis, Osteoarthritis, Rheumatoid Arthritis	Chemical Pharmaceuticals	1	180%	2	Bromination, Friedel-Crafts Acylation	2010	2.4	222789.9	0	0
Minoxidil	Anti-hypertensive	Hypertension And Baldness	Chemical Pharmaceuticals	221	61%	104	Oxidation	2019	4.3	973.5	53.57	2.8
Naphazoline	Anti-histamine	Relieve Redness, Puffiness, Itchy,Watering Eyes Due To Colds, Allergies	Chemical Pharmaceuticals	3	263%	4	Heterocyclization, cyclization reaction	--	--	0.2	0.08	0
Methyl Dopa	Anti-hypertensive	Hypertension	Biotech & Biochemicals	52	52%	46	Condensation, Darzens Condensation, Darzens Condensation Reaction, Decarboxylation, Resolution, Strecker Synthesis	--	--	740.7	4.12	91.73
Phenazopyridine	Pain Management	Lower Urinary Discomfort And Pain	Chemical Pharmaceuticals	8	227%	6	Chichibabin Reaction, Diazotization	--	9.0	46	22.87	0
Baclofen	Pain Management	Muscle Relaxer And Spastic Agent, Pain	Chemical Pharmaceuticals	67	97%	39	Acetoacetate Cleavage, Amine Alkylation, C-Alkylation, Chlorination, Chlorosulfonation, Claisen Condensation, Claisen Schmidt Condensation, Cyclization, Decarboxylation, Hoffmann Reaction, Michael Addition, No2-Reduction, Resolution, Schmidt Reaction	2018	8.1	107.1	2.38	3.84
Methoxyphenamine Hydrochloride	Anti-asthmatic	Asthma, Chronic Obstructive Pulmonary Disease (Copd) And Postinfectious Cough	Biotech & Biochemicals	82	52%	70	--	1973	2.2	507	119.71	67.48
Captopril	Anti-hypertensive	Renovascular Hypertension,Congestive Heart Failure	Chemical Pharmaceuticals	27	374%	32	Amidation, Michael Addition, S-Alkylation	2010	--	85.4	9.07	7.28
Racepinephrine Hydrochloride	Anti-asthmatic	Asthma	Biotech & Biochemicals	--	92%	1	Reduction reaction, separation and purification	--	4.8	--	0	0
Metaxalone	Pain Management	Painful Peripheral Musculoskeletal Conditions And Spasticity From Upper Motor Neuron Syndrome	Chemical Pharmaceuticals	15	488%	20	Oxazolone Synthesis	2021	8.3	64.3	3.52	0.42
Tapentadol	Pain Management	Pain	Chemical Pharmaceuticals	4	189%	8	Acylation, Bromination, Chlorination, Chromatographic Resolution, Esterification, Grignard Reaction, Mannich Reaction, N-Acylation, Nitration, Nitro Reduction, N-Methylation, O-Acylation, O-Methylation, Reduction, Resolution, Sandmeyer Reaction	--	6.1	0.4	0.53	0
Bromural	Pain Management	Sedative, Pain, Anxiety	Chemical Pharmaceuticals	1	90%	--	Biosynthesis, Bromination	--	--	0.1	0	0
Mephenoxalone	Pain Management	Muscle Spasms	Biotech & Biochemicals	--	33%	1	Phosgenation	--	2.5	--	0	0
Bufexamac	Pain Management	Skin Conditions, Pain	Chemical Pharmaceuticals	1	468%	2	Biosynthesis	--	8.5	5.6	0	0.12
Terbutaline	Anti-asthmatic	Bronchospasm associated with asthma	Chemical Pharmaceuticals	--	106%	2	--	2011	4.5	3.9	5.73	0
Ibuprofen Sodium	Anti-Gout	Moderate Pain Related To Dysmenorrhea, Headache, Migraine, Postoperative Dental Pain, Spondylitis, Osteoarthritis, Rheumatoid Arthritis	Chemical Pharmaceuticals	11	56%	40	Amination, Biosynthesis, Fermentation	--	3.0	39.7	0.89	0.41
Nabumetone	Anti-Gout	Rheumatoid Arthritis Osteoarthritis	Chemical Pharmaceuticals	--	38%	1	Microbiological dehydrogenation	1994	11.8	786	0	0
Etafedrine Hydrochloride	Anti-asthmatic	Common Cold And Allergy, Bronchial Asthma, Cough	Biotech & Biochemicals	1	11%	1	--	--	6.5	0.9	0	0
Clonidine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	3	285%	8	Methylation, subsequent reaction	1986	4.4	0	0.01	0
Naproxen	Pain Management	Headache, Muscle Aches, Tendonitis, Dental Pain, And Menstrual Cramps	Chemical Pharmaceuticals	222	15%	51	Acetalization, Bromination, Chlorination, Friedel-Crafts Reaction, Halogenation, Hydro De-Halogenation, Mesylation, O-Alkylation, O-Mesylation, Resolution	1992	5.8	6199.1	688.35	134.77
Ibudilast	Anti-asthmatic	Asthma, Cerebrovascular Disease	Chemical Pharmaceuticals	1	184%	2	Acylation, Bromination, Friedel-Crafts Acylation	--	5.6	0	1.93	0
Propyphenazone	Pain Management	Pain	Chemical Pharmaceuticals	30	79%	16	coupling of BMP REACTION, REFLUX METHOD	--	8.3	271	81.81	0
Aminophenazone	Anti-Gout	Fever & Pain Of Rheumatism, Neuritis & Common Colds	Chemical Pharmaceuticals	31	109%	43	Amidation, Amine Alkylation, Bromination, Chlorination, Formylation, Oxidation	1999	9.9	8.9	0.02	0.99
Lidocaine	Pain Management	Painassociated with post-herpetic neuralgia	Chemical Pharmaceuticals	229	24%	62	Amidation, Amine Alkylation, Reduction reaction, Acid-base reaction	2011	8.4	2816.9	213.44	2.68
Zileuton	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	18	287%	9	Hydrogenation	2010	5.7	7.7	0.15	0
Medetomidine Hydrochloride	Pain Management	Sedation And Analgesia (Veterinary)	Biotech & Biochemicals	1	8%	6	Carbonyl oxidation, diazotization, esterification, grignard reaction, imidazole reaction	--	--	0	0	0
Dexmedetomidine Hydrochloride	Pain Management	Sedative, Pain, Anxiety	Chemical Pharmaceuticals	25	25%	26	Bromination, Diazotization, Friedel-Crafts Acylation, Grignard Reaction, Resolution	2032	9.5	11.2	0	0
Ketamine	Pain Management	Anaesthesia, Pain	Biotech & Biochemicals	1	245%	1	Quenching, thermal rearrangement	--	6.7	27.1	0.03	--
Theophylline Acetic Acid	Anti-asthmatic	Bronchodilator, Cardiotonic, Diuretic	Chemical Pharmaceuticals	10	166%	9	Acylation, Bromination, Friedel-Crafts Acylation, Phosgenation	--	6.5	29	1.17	0
Emorfazone	Pain Management	Toothache	Chemical Pharmaceuticals	1	78%	3	--	--	--	0.9	0	0
Salbutamol	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	120	426%	47	Oxidation, acid catalysis, reduction	--	2.7	7.5	1.84	0.06
Pheniramine	Anti-allergic	Allergy	Chemical Pharmaceuticals	2	23%	2	Amine Alkylation, C-Alkylation, C-Arylation, N-Arylation	--	7.7	0	6.9	0
Pheniramine Maleate	Anti-allergic	Allergy	Chemical Pharmaceuticals	198	41%	70	C-Alkylation, C-Arylation	--	5.6	378.1	53.92	0.23
Methocarbamol	Pain Management	Skeletal Muscle Pain Conditions	Chemical Pharmaceuticals	96	46%	44	Phosgenation	--	7.4	4799	376.39	1.83
Mefenamic Acid	Anti-Gout	Rheumatoid Arthritis, Osteoarthritis, Dysmenorrhea, And Mild To Moderate Pain, Inflammation, And Fever	Chemical Pharmaceuticals	23	555%	31	Amidation, Imine Synthesis, N-Acetylation, No-Reduction, Resolution	--	11.2	1375	0.13	0.04
Moxonidine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	14	217%	14	Carbonyl Reduction, Catalytic Hydrogenation	--	4.6	0.1	0.09	0.03
Xylometazoline	Anti-histamine	Nasal Congestion And Minor Inflammation Due To Allergies Or Colds	Chemical Pharmaceuticals	8	284%	2	Chloromethylation	--	--	0.2	0.74	0
Chlorphenesin Carbamate	Pain Management	Musclepainand spasms	Chemical Pharmaceuticals	5	55%	7	Hydrolysis, charcolisation	--	3.5	8.2	9.57	0
Loxoprofen	Pain Management	Pain And Inflammation	Chemical Pharmaceuticals	6	66%	7	C-Methylation, Decarboxylation, Halogenation, N-Methylation, Radical Halogenation	--	8.1	0	1.12	0
Naphazoline Hydrochloride	Anti-histamine	Relieve Redness, Puffiness, Itchy,Watering Eyes Due To Colds, Allergies	Chemical Pharmaceuticals	37	615%	17	Heterocyclization, cyclization reaction	2027	--	5	0.79	0.03
Pyridoxal Phosphate	Vitamin	Nutritional Supplementation And For Treating Dietary Shortage Or Imbalance	Biotech & Biochemicals	3	52%	1	Enzyme pyridoxal kinase	--	3.4	0	0.09	1
Nimesulide	Anti-Gout	Pain, PainfulOsteoarthritis	Chemical Pharmaceuticals	39	250%	20	Carboxylation, Friedel-Crafts Reaction, Grignard Reaction, Resolution	2014	8.8	2415.3	7.55	1.8
Isoprenaline Hydrochloride	Anti-asthmatic	Bradycardia & Asthma	Chemical Pharmaceuticals	3	123%	1	Friedel-Crafts Reaction	--	6.2	0	0.01	0
Pindolol	Anti-hypertensive	Hypertension, Edema, Ventricular Tachycardias, Atrial Fibrillation	Chemical Pharmaceuticals	3	149%	10	Amine Alkylation, C-Alkylation, Carbonyl Reduction, N-Alkylation, O-Alkylation	1986	--	0	0	0
Phenazopyridine Hydrochloride	Pain Management	Lower Urinary Discomfort And Pain	Chemical Pharmaceuticals	110	78%	44	Chichibabin Reaction, Diazotization	2028	10.3	795	71.94	0.56
Diflunisal	Pain Management	Inflammatory, Pain postoperative	Chemical Pharmaceuticals	15	17%	10	Demethylation, Desilylation, Diazotization, Fluorination, Gomberg-Bachmann Reaction, Hydrogenation, Kolbe-Schmitt Reaction, Nitration	1989	8.0	29	2.66	0.01
Lacosamide	Pain Management	Neuropathic Pain, Pain	Chemical Pharmaceuticals	63	29%	45	Phase transfer catalyst process, Benzylation	2014	8.2	29.5	6.33	0.04
Fenyramidol Hydrochloride	Pain Management	Pain, Muscle Relaxant	Chemical Pharmaceuticals	11	50%	7	Amidation, Carbonyl-Reduction, N-Alkylation	--	9.1	381.8	0	0
Crisaborole	Pain Management	Atopic Dermatitis, Pain	Chemical Pharmaceuticals	6	115%	10	Boronic acid formation, carbonyl reduction, O alkylation and arylation	2026	9.1	0	0.01	0
Naproxen Sodium	Pain Management	Headache, Muscle Aches, Tendonitis, Dental Pain, And Menstrual Cramps	Chemical Pharmaceuticals	100	418%	56	Acetalization, Bromination, Chlorination, Friedel-Crafts Reaction, Hydro De-Halogenation, O-Alkylation, O-Mesylation, Resolution	2014	7.6	2905.2	27.47	33.9
Triamterene	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	14	112%	20	condensation reaction kettle	--	--	53.9	0	3.49
Tizanidine	Pain Management	Muscle Spasms	Chemical Pharmaceuticals	5	368%	7	Catalytic hydrogenation and reduction, cyclization, nitration, catalytic hydrogenation and reduction, condensation and salification	--	8.2	0.1	3.13	0.14
Dexketoprofen	Pain Management	Inflammation, Musculoskeletal Pain, Pain	Chemical Pharmaceuticals	29	333%	8	Friedel-Crafts Reaction, Resolution	--	6.5	248.6	0.15	0
Ketoprofen	Anti-Gout	Chronic Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Primary Dysmenorrhea And Mild To Moderate Pain Associated With Musculotendinous Trauma (Sprains And Strains), Postoperative (Including Dental Surgery) Or Postpartum Pain	Chemical Pharmaceuticals	--	--	1	Bromination, Carbonyl Reduction, Curtius Rearrangement, Cyclization, Dehydration, Fischer Indole Synthesis, Hydrogenolysis, Hydrolysis, Thionation	1991	13.2	785.5	0	0
Nepafenac	Pain Management	Eye Pain	Chemical Pharmaceuticals	26	20%	23	Amidation, Amine Alkylation, C-Arylation, No-Reduction, S-Alkylation	2014	7.9	0	0.02	0
Amfenac	Pain Management	Pain And Inflammation	Chemical Pharmaceuticals	1	41%	--	Amination, Fischer Indole Synthesis, Friedel-Crafts Acylation	--	7.5	0	0.09	0
Ketorolac	Pain Management	Pain	Chemical Pharmaceuticals	8	495%	8	Aromatic Nucleophilic Substitution, Bromination, Cyclopropane Cleavage, Decarboxylation, Enamine Synthesis, Iodination, Iodition, Mesylation, Vilsmeier-Haack Reaction	--	9.1	10.9	9.53	0.04
Diphenhydramine	Anti-histamine	Sneezing, Runny Nose, Itchyandwatery Eyes, Itching Of Nose Or Throat, Insomnia, Pruritis, Urticaria, Insect Bitesandstings, Allergic Rashes, And Nausea	Chemical Pharmaceuticals	14	26%	12	Bromination	--	2.0	229.8	16.18	0
Tapentadol Hydrochloride	Pain Management	Pain	Chemical Pharmaceuticals	39	545%	22	Acylation, Bromination, Chlorination, Chromatographic Resolution, Esterification, Grignard Reaction, Mannich Reaction, N-Acylation, Nitration, Nitro Reduction, N-Methylation, O-Acylation, O-Methylation, Reduction, Resolution, Sandmeyer Reaction	2017	8.2	2.9	3.39	0
Salsalate	Anti-Gout	Rheumatoid Arthritis, Osteoarthritis And Related Rheumatic Disorder	Chemical Pharmaceuticals	41	18%	54	Hydrolysis, underpressure distillation, recrystallization	--	6.4	71.1	210.94	0.8
Menadiol Diacetate	Vitamin	Hypoprothrombinemia	Biotech & Biochemicals	1	67%	1	Friedel-Crafts Reaction, Oxidation	--	7.8	0.4	0	0
Propranolol	Anti-hypertensive	Hypertension, Heartburn, Arhythmia	Chemical Pharmaceuticals	3	18%	11	Epoxidation reaction	--	--	1.4	4.43	0.57
Tiaprofenic Acid	Pain Management	Anti-Inflammatory, Analgesic	Chemical Pharmaceuticals	1	35%	3	Bromination, hydrolysis, Friedel-Crafts reaction	--	8.3	0.4	0.46	0.02
Suprofen	Pain Management	Painand inflammation after cataract surgery	Biotech & Biochemicals	1	174%	1	Acylation, Friedel-Crafts Acylation	1994	4.8	0	0	0
Carisoprodol	Pain Management	Spasm	Chemical Pharmaceuticals	87	74%	42	Phosgenation	--	9.5	2802.2	282.87	35.7
Oxymetazoline	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	4	181%	4	Chloromethylation	--	7.3	24.3	0.44	0.01
Norcyclobenzaprine	Pain Management	Relax Muscles And RelievePain	Biotech & Biochemicals	1	--	1	--	--	--	--	0	0
Tolfenamic Acid	Pain Management	Migraine	Chemical Pharmaceuticals	18	75%	12	Analgesic, Antiinflammatory	--	7.6	16.4	18.13	0
Tramadol	Pain Management	Pain	Chemical Pharmaceuticals	6	64%	18	Bromination, Grignard Reaction, Mannich Reaction, Methoxydenitration, N-Methylation, O-Methylation, Sandmeyer Reaction	--	7.3	1.2	29.89	1
Nortriptyline	Pain Management	Chronicpain, diabetic neuropathy, myofascialpain, orofacialpain, postherpetic neuralgia	Chemical Pharmaceuticals	4	135%	3	Acylation, Bromination, Friedel-Crafts Acylation	--	6.4	0.1	7.91	2.71
Fenoprofen Sodium	Anti-Gout	Rheumatoid Arthritis, Osteoarthritis	Biotech & Biochemicals	879	45%	310	Carbonylation, Grignard Reaction, Pyrolysis	--	--	--	5325.49	1341.96
Ibuprofen Sodium Dihydrate	Pain Management	Pain, Inflammation	Biotech & Biochemicals	5	19%	4	Friedel-Crafts acylation, reduction, chloride substitution, and Grignard reaction	--	--	9.5	1.72	0.11
Thiamine	Vitamin	Thiamine And Niacin Deficiency States, Korsakov'S Alcoholic Psychosis, Wernicke-Korsakov Syndrome, Delirium, And Peripheral Neuritis	Biotech & Biochemicals	73	--	47	Fementation	--	4.6	766	61.52	618.35
Amiloride Hydrochloride	Anti-hypertensive	Hypokalemia in Hypertension Patients	Chemical Pharmaceuticals	70	32%	28	Amidation, Catalytic Hydrogenation, N-Arylation, Oxidation, Chlorination, C-Oxidation, Nitrozation, No-Reduction	1998	--	24.2	1.75	0.23
Doxofylline	Anti-asthmatic	Asthma, Bronchitis, Chronic Obstructive Pulmonary Disease	Chemical Pharmaceuticals	1	413%	--	Bromination, N-Methylation	--	5.5	446.5	0.01	0
Atenolol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	424	124%	115	Amine Alkylation, Condensation, Cyanation, Hydrolysis, N-Alkylation, Nitrile Hydrolysis, O-Alkylation	1989	--	2612.1	411.06	18.28
Cyclizine	Anti-histamine	Antiemetic, Antihistaminic, Antiemetic (Veterinary)	Chemical Pharmaceuticals	8	18%	2	EschweilerClarke methylation	--	--	4.3	0.26	0
Metoprolol	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	10	194%	8	Butyllithium, Oxirane Amination, Oxirane Synthesis	--	--	134.2	29.99	0.12
Rizatriptan	Pain Management	Migraine	Chemical Pharmaceuticals	8	725%	8	Bromination	--	7.3	0.1	0.06	0
Orphenadrine	Pain Management	Muscle Spasm, Pain	Biotech & Biochemicals	1	45%	--	--	--	--	--	4.14	0.04
Leflunomide	Anti-Gout	Rheumatoid Arthritis	Chemical Pharmaceuticals	--	--	--	--	1999	14.5	21.3	0	0
Doxylamine	Anti-histamine	Allergies, Antitussive, Emesis, Hypnotic	Biotech & Biochemicals	4	146%	7	Bromination	--	--	69.4	5.09	0
Lidocaine Hydrochloride	Pain Management	Painassociated with post-herpetic neuralgia	Chemical Pharmaceuticals	412	54%	101	Reduction reaction, Acid-base reaction	2014	5.6	1457.2	233.51	2.55
Zoledronic Acid	Pain Management	Multiple Myeloma, Bone Metastases From Solid Tumors, Pain	Chemical Pharmaceuticals	72	601%	31	Nucleophilic substitution	2012	5.3	1.6	0.01	0
Carprofen	Pain Management	Joint Pain And Post-Surgical Pain	Chemical Pharmaceuticals	14	466%	36	Friedel-Crafts Reaction	1994	7.3	55.7	0.12	0.08
Ketamine Hydrochloride	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	64	68%	30	Bromination, Cyanation, Friedel-Crafts Acylation, Grignard Reaction, Photochlorination	2033	7.1	119.5	9	0
Dexchlorpheniramine	Anti-histamine	Allergic Rhinitis	Biotech & Biochemicals	--	175%	1	--	--	--	25.5	0.01	0
Chlorpheniramine	Anti-allergic	Rhinitis, Urticaria, Allergy, Common Cold, Asthma And Hay Fever	Chemical Pharmaceuticals	8	379%	13	Condensation, Cyanation, Cyclization, Decarboxylation, Halogenation, Heteroaromatic Nucleophilic Substitution, Radical Halogenation	--	4.5	24.4	14.19	0.01
Cyclobenzaprine	Pain Management	Musculoskeletal Pain	Chemical Pharmaceuticals	12	671%	5	Condensation, Co reduction, cyanation, cyclization, friedal crafts reaction	--	9.8	8.3	0.77	0.09
Albuterol Hydrochloride	Anti-asthmatic	Asthma, Chronic Obstructive Pulmonary Disease	Biotech & Biochemicals	2	145%	2	Quaternisation	--	5.1	--	0	0
Levalbuterol Hydrochloride	Anti-asthmatic	Asthma	Biotech & Biochemicals	70	49%	31	Bromination, Cyanation, Esterification, Friedel-Crafts Acylation, Quaternisation	2010	8.9	0.9	0.25	0.05
Menadione Sodium Bisulfite	Vitamin	Mitigate The Toxicity Of Organophosphorus Pesticides Including Parathion	Biotech & Biochemicals	15	156%	10	Fermentation	--	8.7	89.5	0.09	13.32
Clenbuterol	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	13	64%	9	Acylation, Cyanation, Esterification, Friedel-Crafts Acylation	--	4.5	1.3	0	0
Amfenac Sodium	Anti-Gout	Painand inflammation associated with rheumatoid and osteoarthritis and low backpain	Chemical Pharmaceuticals	12	19%	7	Carbonylation, Grignard Reaction, Pyrolysis	--	7.5	0.2	4.29	0.02
Rilmenidine Dihydrogen Phosphate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	84%	2	--	2019	--	0	0	0
Pentoxifylline	Pain Management	Intermittent Lameness Or Immobility Arising From Chronic Occlusive Arterial Disease Of The Limbs. Pain	Chemical Pharmaceuticals	182	245%	48	Bromination	1997	8.1	3798.1	463.91	0.07
Triprolidine	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	3	154%	4	Acylation, Bromination, Friedel-Crafts Acylation, Mannich Reaction	--	--	0.1	0.05	0
Tolmetin Sodium	Anti-Gout	Rheumatoid Arthritis And Osteoarthritis, Acute Flares Long-Term Management Also For Of Juvenile Rheumatoid Arthritis	Chemical Pharmaceuticals	1	--	--	Recombinant technology	1990	6.1	1.3	0	0
Flufenamic Acid	Anti-Gout	Rheumatic Disorders	Chemical Pharmaceuticals	59	461%	25	Bromination	--	9.2	0	106.53	0.71
Phentolamine	Anti-hypertensive	Diagnosis Of Pheochromocytoma, Hypertension	Biotech & Biochemicals	1	63%	--	Alkylation	--	--	0	0	0
Tolperisone Hydrochloride	Pain Management	Neurologic Disorder, Spasm	Chemical Pharmaceuticals	16	772%	15	Friedel-Crafts Reaction	--	8.1	42.2	14.08	0.04
Niflumic Acid	Pain Management	Anti-Inflammatory, Analgesic	Chemical Pharmaceuticals	3	112%	3	ketalization,phosphorylation, Ammination	2003	7.6	8.6	0	0.36
Guanfacine Hydrochloride	Anti-hypertensive	High Blood Pressure, Relief From Congested Chests And Coughs Which May Be Due To A Cold, Bronchitis	Chemical Pharmaceuticals	7	35%	11	Chlorination, Cyanation, Dehydroxy-Chlorination	2015	--	0.6	0	0.03
Ozagrel Hydrochloride Hydrate	Anti-asthmatic	Cerebral Vasospasm And Asthma	Biotech & Biochemicals	22	507%	11	Adol Condensation Reaction, Bromination, Oxime Synthesis, Urea Synthesis	--	4.1	--	1.13	0
Choline Theophyllinate	Anti-asthmatic	Asthma, Bronchitis, Copd, And Emphysema	Chemical Pharmaceuticals	13	50%	13	Diastereomeric Separation, Esterification, Fermentation, Ketalization	--	4.1	3.3	0.02	0
Pethidine Hydrochloride	Pain Management	Anti-Inflammatory, Analgesic	Chemical Pharmaceuticals	7	22%	11	C-Alkylation, Chlorination, N-Alkylation	--	7.1	0.5	0.08	0.1
Morphine	Pain Management	Addiction Disorder And Drug Abuse, Pain	Chemical Pharmaceuticals	5	148%	12	Gates synthesis, Rice synthesis	--	7.6	0.3	0	0.03
Probenecid	Anti-Gout	Gout	Chemical Pharmaceuticals	209	265%	69	Diazotization, Diazotation, N-Bromination	--	10.2	57.9	53.09	0.1
Pyrilamine	Anti-allergic	Allergy	Chemical Pharmaceuticals	2	61%	4	Hydrolysis	--	6.1	10.8	9.17	0
Pentazocine	Pain Management	Pain	Chemical Pharmaceuticals	9	145%	5	Bromination	2022	7.7	0.5	0.29	0.04
Epinastine Hydrochloride	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	8	11%	21	Amide Deoxo Chlorination, Cnitro-Reduction, Cyanation, Isocyanate Synthesis, Phosgenation	2020	9.3	1.3	0.27	0
Thonzylamine	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	1	64%	--	--	--	--	0.2	0.02	0
Trolamine Salicylate	Pain Management	Aches, And Pains Of Muscles And Joints	Chemical Pharmaceuticals	1	9%	--	--	--	--	0.1	0.02	0
Etodolac	Pain Management	Postoperative Pain	Chemical Pharmaceuticals	98	65%	64	Amine Alkylation, Decarboxylation, Dehydration, Diazotization, Hydrogenation, Aniline Ortho-Olefination, C=C-Hydrogenation, Diazonium Reduction, Diazotation, Fissher Indole Synthesis, High Pressure, High Temperature, Hydroformylation	1993	7.9	540.9	47.25	0.27
Zolmitriptan	Pain Management	Migraine	Chemical Pharmaceuticals	62	181%	39	Amine Alkylation, Carbonylation, Carbonyl Reduction, Chlorination, Diazotization, Fermentation, Fischer Indole Synthesis, N-Alkylation, Nitration, Nitro-Reduction, No-Reduction, Phosgenation, Rosenmund Reaction, Rosenmund Reduction	2012	7.4	15.1	0.11	0
Dihydralazine Sulfate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	5	111%	3	--	--	2.1	8.2	0	0
Nefopam Hydrochloride	Pain Management	Acute And Chronic Pain	Chemical Pharmaceuticals	23	68%	13	Amidation reaction, Reduction reaction, Cyclization reaction	--	7.7	2	0.01	0.22
Zoledronic Acid Monohydrate	Pain Management	Multiple Myeloma, Bone Metastases From Solid Tumors, Pain	Chemical Pharmaceuticals	24	524%	22	Nucleophilic substitution	--	5.3	0.1	0	0
Nicotinamide-Beta-Riboside Chloride	Vitamin	Diabetes, Heart Disease, AlzheimerS Disease And Vision Loss	Biotech & Biochemicals	1	21%	--	Coupling Reaction, acylation, condensation, glycosylation, FriedelCrafts catalysts	--	--	--	0	0
Carbinoxamine	Anti-histamine	Allergic And Vasomotor Rhinitis, Conjunctivitis, Urticaria, Angioedema, Reaction To Blood, Adjunct In Anaphylaxis, Dermatographism	Chemical Pharmaceuticals	1	9%	--	Williamson ether synthesis	2021	10.2	3.6	0.21	0
Diphenhydramine Hydrochloride	Anti-histamine	Sneezing, Runny Nose, Itchyandwatery Eyes, Itching Of Nose Or Throat, Insomnia, Pruritis, Urticaria, Insect Bitesandstings, Allergic Rashes, And Nausea	Chemical Pharmaceuticals	310	100%	115	Bromination	2034	--	1789.5	206.5	0.68
Dimetindene	Anti-allergic	Urticaria, Allergies Of The Upper Respiratory Tract Such As Hey Fever And Perennial Rhinitis, Food And Drug Allergies, Chicken-Pox	Chemical Pharmaceuticals	--	64%	1	Acylation, Friedel-Crafts Acylation	--	6.3	0.3	0	0
Ondansetron	Pain Management	Pain And Nausea And Vomiting Associated With Emetogenic Cancer Chemotherapy	Chemical Pharmaceuticals	42	628%	36	Carbonyl Reduction, Catalytic Hydrogenation, Mannich Reaction, N-Acetylation, N-Alkylation	2015	7.9	1.5	2.14	0
Alosetron	Pain Management	Irritable Bowel Syndrome pain	Chemical Pharmaceuticals	1	212%	1	Beckmann Rearrangement, Bromination, Catalytic Hydrogenation, Chlorination, Fermentation, Fischer Indole Synthesis, Hydroxymethylation, Imidazole Synthesis, N-Alkylation, Oxime Synthesis, Pyridine Synthesis, Amidation, C-Oxidation, N-Arylation, Nitrozation	--	3.5	0	0	0
Pizotifen	Pain Management	Migraines	Chemical Pharmaceuticals	1	121%	1	Grignard coupling	--	--	0	0	0
Sumatriptan	Pain Management	Migraine, Cluster Headaches	Chemical Pharmaceuticals	44	223%	25	Fischer indole synthesis	2011	9.5	16.6	2.51	0
Chlorothiazide	Anti-hypertensive	Congestive Heart Failure, Hepatic Cirrhosis, Corticosteroid And Estrogen Therapy	Chemical Pharmaceuticals	23	113%	17	Sulfoylchlorination	--	--	1.8	1.2	0.21
Propranolol Hydrochloride	Anti-hypertensive	Hypertension, Heartburn, Arhythmia	Chemical Pharmaceuticals	152	65%	66	Epoxidation reaction	2021	--	613.2	75.69	11.07
Diclofenac	Pain Management	Pain And Inflammation	Chemical Pharmaceuticals	147	81%	37	Amine Alkylation, Carbonate Synthesis, Carbonyl Reduction, Chlorination, Condensation, Cyanation, Cyclopropanation, Decarboxylation, Friedel-Crafts Reaction, N-Alkylation, N-Arylation, O-Alkylation	2030	3.9	3783.1	109.79	15.19
Guanethidine Monosulfate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	13%	1	--	--	--	--	0	0
Duloxetine	Pain Management	Diabetic Peripheral Neuropathic Pain	Chemical Pharmaceuticals	22	99%	23	Condensation, Desilylation, Mannich Reaction, Nitration, Resolution, Schiemann Reaction, Co Reduction, Diazotation, Friedel-Crafts Reaction, Mannich Condensation Reaction, N-Demethylation, No-Reduction	--	4.2	737.2	69.77	0.01
Hydrochlorothiazide	Anti-hypertensive	Hypertension, Edema Associated With Congestive Heart Failure,Nephrotic Syndrome, Acute Glomerulonephritis, Chronic Renal Failure, And Corticosteroid And Estrogen Therapy	Chemical Pharmaceuticals	447	96%	125	Chlorination, Alkylation	2007	--	148472.9	165.06	19.13
Nitroprusside Sodium	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	44%	1	Concentrated crystallization	--	--	--	0.02	0
Cicletanine Hydrochloride	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	125%	1	eNOS phosphorylation	--	--	--	0	0
Tamadol Hydrochloride	Pain Management	Pain	Chemical Pharmaceuticals	20	204%	14	Bromination, Grignard Reaction, Mannich Reaction, Methoxydenitration, O-Methylation, Sandmeyer Reaction	2011	7.3	183	0	0
Tramadol Hydrochloride	Pain Management	Pain	Chemical Pharmaceuticals	550	64%	158	Bromination, Grignard Reaction, Mannich Reaction, Methoxydenitration, N-Methylation, O-Methylation, Sandmeyer Reaction	2014	6.0	2602.8	394.3	5.41
Dihydrocodeine	Pain Management	Severe Pain, Severe Dyspnea, And Cough	Chemical Pharmaceuticals	--	39%	1	Carbonyl Reduction, Hydrogenation, N-Methylation	--	--	--	0	0.37
Oxprenolol Hydrochloride	Anti-hypertensive	Hypertension, Angina Pectoris, Arrhythmias, And Anxiety.	Chemical Pharmaceuticals	4	207%	5	--	1986	--	--	0	0
Cyclizine Hydrochloride	Anti-histamine	Antiemetic, Antihistaminic, Antiemetic (Veterinary)	Chemical Pharmaceuticals	20	19%	5	EschweilerClarke methylation	--	--	29.8	1.68	0.31
Fenoterol	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	13	8%	11	Nitrosation	--	4.8	0.1	1.59	0
Loxoprofen Sodium Hydrate	Pain Management	Painand inflammation related to musculoskeletal and joint disorders	Chemical Pharmaceuticals	13	284%	35	C-Methylation, Decarboxylation, Halogenation, N-Methylation, Radical Halogenation	--	--	7.2	0	0
Flupirtine	Pain Management	Fibromyalgia	Chemical Pharmaceuticals	1	85%	--	Phosgenation	--	--	0.3	0.2	0
Capsaicin	Pain Management	Neuropathic Pain, Pain	Chemical Pharmaceuticals	61	311%	63	Amidation, Biosynthesis, Bromination, Double Bond Isomerisation, Extraction (Biotechnology), Nitro-Reduction, Oximation, Wittig Reaction	2021	4.3	179.5	0	0.19
Fenoldopam	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	31%	1	Bromination, Chlorination, Condensation, Diels-Alder Reaction, Epoxidation, Hydrogenation, Knoevenagel Condensation	--	--	--	0	0
Orphenadrine Hydrochloride	Pain Management	Discomfort Associated With Acute Painful Musculo Skeletal Conditions	Chemical Pharmaceuticals	4	187%	2	Friedel-Crafts Reaction	--	8.2	3.2	0.09	0.03
Alcaftadine	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	5	210%	7	Amine Alkylation, Carbonyl Oxidation, Cyanation, Cyclization, Decarboxylation, Hydroxymethylation, N-Alkylation, N-Methylation, Oxidation	2027	5.4	0	0	0
Betaxolol	Anti-hypertensive	Hypertension,Glaucoma	Chemical Pharmaceuticals	4	115%	1	Amine Alkylation, Carbonate Synthesis, Carbonyl Reduction, Hydrogenolytic Debenzylation, N-Alkylation, O-Alkylation, O-Benzylation	2024	--	0	0	0.01
Normorphine Hydrochloride	Pain Management	Chronic, Moderate To Severe Pain	Chemical Pharmaceuticals	1	75%	--	Hydrolysis and hydrogenation	--	--	0	0	0
Dextromethorphan Hydrochloride	Anti-allergic	Cough, Allergy	Chemical Pharmaceuticals	1	302%	5	Grewe's cyclization	2028	7.2	0.1	0.29	0
Nadolol	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	7	525%	5	Hydrogenation, acetylation, Woodwards synthesis	1993	4.1	8.6	29.95	10.17
Benzydamine	Pain Management	Myalgia And Bursitis	Chemical Pharmaceuticals	3	405%	2	Amine Alkylation, N-Alkylation, Nitrosation, No-Reduction, O-Alkylation	--	2.2	1.5	0.76	0
Methadone	Pain Management	Opioid Analgesic, Pain	Chemical Pharmaceuticals	4	37%	5	Acylation, Bromination, Friedel-Crafts Acylation	2015	8.9	0	0.33	0
Desloratadine	Anti-histamine	Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria, Chronic Idiopathic Urticaria (Ciu), Allergic Rhinitis (Ar)	Chemical Pharmaceuticals	386	46%	85	Amidation, amine alkylation, bromination, carbamate synthesis	2014	5.8	74.7	12.51	0.05
Metamizole Sodium Monohydrate	Pain Management	Fever, Pain	Chemical Pharmaceuticals	--	7%	2	Alkylation, Friedel-Crafts-reaction, condensation, Mannich-reaction	--	--	--	1.6	48.23
Metamizole	Pain Management	Fever, Pain	Chemical Pharmaceuticals	4	25%	2	Alkylation, Friedel-Crafts-reaction, condensation, Mannich-reaction	--	7.1	709.3	0	4.34
Clenbuterol Hydrochloride	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	6	185%	4	Acetylation, Alcohol Oxidation, Amination, Amine Alkylation, Bromination, Carbamatation, Carbonyl Reduction, Chlorination, Fischer Indole Synthesis, Friedel-Crafts Reaction, Imine Reduction, Imine Synthesis, O-Alkylation, Oh Oxidation, Oxidation	2027	7.7	0.3	0.01	0
Sapropterin Dihydrochloride	Anti-hypertensive	Hypertension, Kidney Disorder	Chemical Pharmaceuticals	10	52%	11	Centrifugation, Concentration, Rectification	2024	--	0.9	0.02	0.12
Rofecoxib	Anti-Gout	Osteoarthritis	Chemical Pharmaceuticals	4	914%	4	Amine Alkylation, Aminophenazone N-Alkylation, Nitrosation, No-Reduction	2013	8.1	0.5	0	0
Valdecoxib	Anti-Gout	Osteoarthritis And Dysmenorrhoea	Chemical Pharmaceuticals	56	53%	53	Bromination, Diazotization, Oxidation, Sandmeyer Reaction	2015	3.8	0	252.38	70.97
Cannabidiol	Pain Management	Disseminated Sclerosis, Pain	Chemical Pharmaceuticals	--	189%	3	Allylic Rearrangement, Condensation, Cyclization, Diazotization, Epoxidation, Hydrogenation, Hydrolysis, Oxidation	2022	--	0	0	0
Triprolidine Hydrochloride	Anti-histamine	Sneezing, Runny Nose, Watery Eyes, Skin Rash, Itching,Cold Or Allergy Symptoms	Chemical Pharmaceuticals	144	434%	51	Acylation, Bromination, Friedel-Crafts Acylation, Mannich Reaction	2018	--	36.4	3.51	0.03
Oxycodone	Pain Management	Moderate To Severe Pain	Chemical Pharmaceuticals	--	34%	2	Alcohol Oxidation, Oxidation	2023	4.6	0	0	0
Phenylephrine Bitartrate	Anti-allergic	Cold, Flu, Allergies	Chemical Pharmaceuticals	13	11%	1	Reflux method	--	9.2	37	4.28	0.07
Coenzyme Q2	Vitamin	Supplement	Biotech & Biochemicals	1	--	--	Fermentation	--	10.0	1984.3	0.39	2.94
Tetrodotoxin	Pain Management	Chronic And Breakthrough Pain, Opioid Dependence	Biotech & Biochemicals	1	214%	1	Extraction (Biotechnology)	2020	--	0	0	0
Promethazine Base	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	1	294%	1	Alkylating phenothiazine	--	--	0.5	0.02	0
Promethazine Hydrochloride	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	133	211%	61	Alkylating phenothiazine	2028	--	235.1	24.15	2.94
Hydromorphone Hydrochloride	Pain Management	Cancer Related Pain	Chemical Pharmaceuticals	1	30%	18	Isomerization, oxidation	2011	--	0	0	0
Mequitazine	Anti-histamine	Hay Fever, Urticaria (Hives) And Allergic Rhinitis	Chemical Pharmaceuticals	3	47%	3	Amine Alkylation, C=C Hydrogenation, Carbonyl Reduction, Chlorination, Cyanation, Deshydratation, N-Alkylation, Nitrile Hydrogenation	2026	--	0.1	0	0.01
Monocrotalin	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	4	15%	--	Regioselective coupling reaction	--	--	0	0	0
Bisoprolol	Anti-hypertensive	Hypertension, Heart Failure, Atrial Fibrillation, Angina Pectoris	Chemical Pharmaceuticals	27	255%	12	Amine Alkylation, Carbonate Synthesis, Carbonyl Reduction, Catalytic Hydrogenation, Chlorination, Chloromethylation, Hydrolysis, N-Alkylation, O-Alkylation, Sodium Borohydride Reduction	2019	4.2	1.6	0.75	0.03
Zoledronic Acid Trihydrate	Pain Management	Multiple Myeloma, Bone Metastases From Solid Tumors, Pain	Chemical Pharmaceuticals	1	305%	1	Nucleophilic substitution	--	5.3	3.9	0	0
Acetyl Salicylate Lysine	Pain Management	Pain	Chemical Pharmaceuticals	14	102%	--	Hydrolysis	1986	6.5	6.2	0	0.36
Thiamine Mononitrate	Vitamin	Thiamine And Niacin Deficiency States, Korsakov'S Alcoholic Psychosis, Wernicke-Korsakov Syndrome, Delirium, And Peripheral Neuritis	Biotech & Biochemicals	148	87%	88	Fementation	--	3.7	6195.6	2.63	189.29
Carteolol Hydrochloride	Anti-hypertensive	Hypertension, Glaucoma, Angina Pectoris, Stenocardia, Tachycardia	Chemical Pharmaceuticals	2	24%	8	Aromatization, En-Amination, Epoxide-Amination, Michael Addition	1994	--	0.1	0	0
Ondansetron Hydrochloride	Pain Management	Pain And Nausea And Vomiting Associated With Emetogenic Cancer Chemotherapy	Chemical Pharmaceuticals	143	443%	62	Crystallization, acidification	2011	7.6	17.6	3.68	0
Oxomemazine	Anti-allergic	Allergy	Chemical Pharmaceuticals	12	73%	4	N-Arylation	--	8.2	10.4	1.37	0
Tienilic Acid	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	22%	1	--	--	--	--	0	0
Piroxicam	Anti-Gout	Osteoarthritis And Rheumatoid Arthritis	Chemical Pharmaceuticals	128	254%	64	Acetalization, Bromination, Carbonyl Oxidation, Carbonyl Reduction, Epoxidation, Fluorination, Grignard Reaction, Iodination, Carbonyl-Oxidation, Carbonyl-Reduction	1988	8.5	145.9	0.5	0.01
Adrenaline Tartrate	Anti-allergic	Severe Allergic Reaction	Chemical Pharmaceuticals	55	177%	27	--	--	7.8	0.5	0.06	0.02
Duloxetine Hydrochloride	Pain Management	Diabetic Peripheral Neuropathic Pain	Chemical Pharmaceuticals	123	44%	106	Co Reduction, Diazotation, Friedel-Crafts Reaction, Mannich Condensation Reaction, N-Demethylation, Nitration, No-Reduction, Resolution, Schiemann Reaction	2013	4.0	3381.1	185.58	1.35
Diclofenac Potassium	Pain Management	Pain	Chemical Pharmaceuticals	233	27%	55	Hydrolisation	2017	6.6	821.8	153.47	0.83
Diclofenac Sodium	Anti-Gout	Osteoarthritis And Rheumatoid Arthritis	Chemical Pharmaceuticals	665	143%	178	Acid-catalyzed cyclization, desulfurization and hydrolysis	2014	3.9	8746.9	1092.61	33.8
Pimecrolimus	Anti-allergic	Atopic Dermatitis	Chemical Pharmaceuticals	27	311%	9	Chlorination, Fermentation, Fermentation (Biotechnology), O-Silylation	2015	6.3	0.1	0	0
Naratriptan	Pain Management	Migraine	Chemical Pharmaceuticals	2	262%	--	Bromination, Diazotization	2028	9.5	4	0	0
Almotriptan	Pain Management	Migraine Headaches	Chemical Pharmaceuticals	--	322%	1	Condensation, cyclization, reduction, diazotization	2025	--	0.3	0.04	0
Firocoxib	Pain Management	Management ofpainand inflammation associated with OA in dogs (Veterinary)	Veterinary Active	2	93%	10	Acylation, Friedel-Crafts Acylation, Oxidation	2037	9.3	0.1	0	0
Fentanyl	Pain Management	Pain	Chemical Pharmaceuticals	2	154%	19	Amidation, Amine Alkylation, Butyllithium, Carbonate Synthesis, Condensation, Cyclopropanation, Dieckmann Condensation, Michael Addition, Reductive Amination, Reductive Debenzylation	2027	3.8	0	0	0
Tenoxicam	Anti-Gout	Rheumatoid Arthritis, Osteoarthritis And Related Rheumatic Disorder	Chemical Pharmaceuticals	150	49%	93	Dehydrogenation, Enzymatic Dehydrogenation (Biotechnology), Enzymatic Hydroxylation (Biotechnology), Enzymatic Reaction (Biotechnology), Hydroxylation, O-Acetylation, Esterification, Phosphorylation	--	10.5	4.7	4.17	29.87
Levosalbutamol Sulphate	Anti-asthmatic	Chronic Obstructive Pulmonary Disease, Asthma	Chemical Pharmaceuticals	--	86%	2	--	--	4.7	5.2	0	0
Olopatadine	Anti-allergic	Seasonal Allergic Rhinitis, Urticaria, Allergic Rhinitis (Ar), Allergic Conjunctivitis	Chemical Pharmaceuticals	6	68%	3	Amine Alkylation, Bromination, Friedel-Crafts Reaction, N-Alkylation, O-Alkylation, Wittig Reaction	2025	5.6	0	0	0
Chlorthalidone	Anti-hypertensive	Hypertension, Congestive Heart Failure, Hepatic Cirrhosis	Chemical Pharmaceuticals	96	223%	39	Friedel-Crafts Reaction, Nitration, Nitro Reduction, Nitro-Reduction	2007	--	193.4	15.56	3.41
Topiramate	Pain Management	Migraine, Epilepsy, Seizures	Chemical Pharmaceuticals	204	524%	79	Hydrolysis, ammonolysis reaction	2015	9.4	274.5	43.63	0.93
Propoxyphene	Pain Management	Moderate Pain	Chemical Pharmaceuticals	1	22%	1	Acylation	--	--	--	0	0
Loratadine Ketone	Anti-histamine	Allergic Rhinitis, Angioedema And Chronic Urticaria	Chemical Pharmaceuticals	1	137%	1	Hydrolysis and isolation	--	1.0	0.1	0	0
Betaxolol Hydrochloride	Anti-hypertensive	Hypertension,Glaucoma	Chemical Pharmaceuticals	29	48%	21	Carbonyl Reduction, Hydrogenolytic Debenzylation, N-Alkylation, O-Alkylation, O-Benzylation	1999	7.8	2	0.77	0.05
Eupatilin	Pain Management	Abdominal Pain Or Diarrhea	Chemical Pharmaceuticals	1	--	1	--	--	--	--	0	0
Clopamide	Anti-hypertensive	Hypertension, Edema	Chemical Pharmaceuticals	1	3%	--	Catalytic hydrogenation, rectification	--	2.7	--	0	0
Benzydamine Hydrochloride	Pain Management	Myalgia And Bursitis	Chemical Pharmaceuticals	89	51%	15	N-Alkylation, Nitrosation, No-Reduction, O-Alkylation	2015	6.6	48.3	6.31	0.51
Levomethadone Hydrochloride	Pain Management	Addiction Disorder And Drug Abuse, Pain	Chemical Pharmaceuticals	4	575%	5	Friedel-Crafts Acylation, N-Bromination	--	5.7	0.3	0.09	0
Methadone Hydrochloride	Pain Management	Opioid Analgesic, Pain	Chemical Pharmaceuticals	29	22%	18	Acylation, Bromination, Friedel-Crafts Acylation	--	4.9	21.7	1.92	0.07
Serratiopeptidase	Pain Management	Pain, Inflammation	Biotech & Biochemicals	38	178%	26	Purification from culture of Serratia E-15	--	9.0	20.1	0.01	0
Nifedipine	Anti-hypertensive	Heart Failure Therapies, Ischaemic Heart Disorder Therapies	Chemical Pharmaceuticals	116	61%	88	Amination, Fischer Indole Synthesis, Hantzsch Pyridine Synthesis, Pyridine Synthesis	2010	4.0	304.6	43.07	1.24
Enalaprilat	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	10	34%	9	Amidation, Amine Alkylation, Butyllithium, Cyclopropanation, Oxidation, Reductive Amination, C=C-Hydrogenation, C-Alkylation, Carbonyl-Oxidation, Cyanohydrin Synthesis, Decarboxylation	2000	--	0	0	0
Acrivastine	Anti-histamine	Seasonal Allergic Rhinitis Such As Sneezing, Rhinorrhea, Pruritus, Lacrimation, And Nasal Congestion	Chemical Pharmaceuticals	3	360%	5	Arbuzov Reaction, Bromination, Butyllithium, Formylation, Friedel-Crafts Reaction, Heck Reaction, Lithiation, Low Temperature Lithiation, Wittig Reaction, Wittig-Horner Reaction	2017	4.5	0	0	0
Meloxicam	Anti-Gout	Osteoarthritis, Ankylosing Spondylitis (As), Acute Gouty Arthritis (Ga), Rheumatoid Arthritis	Chemical Pharmaceuticals	1	38%	1	Condensation	2019	17.5	216.7	0	0
Oxycodone Hydrochloride	Pain Management	Opioid Analgesic, Pain	Chemical Pharmaceuticals	1	281%	16	Oxidation, hydrogenation	2013	7.9	0	0	0
Raubasine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	8%	1	--	--	--	0.1	0.05	0
Ibuprofen Lysine	Pain Management	Pain, Inflammation	Chemical Pharmaceuticals	2	50%	21	--	2020	8.8	223	9.96	13.89
Epoprostenol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	59%	1	Bromination	2026	5.3	--	0	0
Protopine	Pain Management	Pain	Chemical Pharmaceuticals	1	73%	--	--	--	--	2415.3	0	0
Aceclofenac	Pain Management	Pain And Inflammation	Chemical Pharmaceuticals	152	66%	64	Arbuzov Reaction, Bromination, Carbonate Synthesis, Carbonyl Reduction, Catalytic Hydrogenation, Chlorination, Cyanation, Cyclization, Decarboxylation, Friedel-Crafts Cyclization, Isatin Synthesis, N-Arylation	--	7.7	574.8	113.08	1.74
Bromfenac Sodium	Pain Management	Ocular Pain And Inflammation	Chemical Pharmaceuticals	11	194%	12	Chlorination, Dehydrogenation, Friedel-Crafts Reaction, Hydrolysis, Sugasawa Reaction	2024	11.1	2.5	0.11	0
Nalbuphine	Pain Management	Moderate To Severe Pain	Chemical Pharmaceuticals	1	60%	3	Bromination	--	--	0	0	0
Prednisone	Anti-allergic	Perennial Or Seasonal Allergic Rhinitis, Exfoliative Dermatitis, Chronic Lymphocytic Leukaemia, Hodgkin'S Or Non-Hodgkin'S Lynphomas	Chemical Pharmaceuticals	42	47%	21	Microbiological dehydrogenation	2020	3.1	52.7	0.11	4.65
Nitrendipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	219%	1	Hantzsch Pyridine Synthesis, Pyridine Synthesis	2012	--	--	0	0
Aldosterone	Anti-hypertensive	Blood-Pressure Regulation And Salt/Water Homeostasis	Chemical Pharmaceuticals	5	102%	2	Enzyme biochemical	--	8.4	0.4	0	0
Cortisone	Anti-asthmatic	Antirheumatic, Antiallergic, Antiasthmatic	Chemical Pharmaceuticals	--	--	--	Enymatic synthesis	1970	3.7	0	0	0
Butyl Scopolamine	Pain Management	Crampy Abdominal Pain, Esophageal Spasms, Renal Colic, And Bladder Spasms	Chemical Pharmaceuticals	1	167%	--	Bromination, crystallization	--	4.3	0	0.08	0
Antazoline Mesylate	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	--	150%	1	--	--	4.5	--	0	0
Hexamethonium Bromide	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	2	62%	--	--	--	--	0	0.01	0
Antazoline Phosphate	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	6	131%	50	--	--	3.8	0	0.02	0
Labetalol Hydrochloride	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	35	84%	30	Bromination, Co-Reduction, Friedel-Crafts Acylation, Reductive Amination	1995	2.8	315.2	9.71	36.26
Indapamide	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	39	366%	38	Decarboxylation, Indoline Synthesis, Nitrozation, No Reduction	1988	1.7	19.9	2.21	0.78
Metolazone	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	16	11%	13	Acylation	2003	--	0.1	0.06	0.01
Ondansetron Hydrochloride Dihydrate	Pain Management	Pain And Nausea And Vomiting Associated With Emetogenic Cancer Chemotherapy	Chemical Pharmaceuticals	197	443%	40	Catalytic Hydrogenation, Mannich Reaction, N-Acetylation, N-Alkylation	2021	7.1	26.4	3.7	0.02
Cloperastine Hydrochloride	Anti-histamine	Dry Cough	Chemical Pharmaceuticals	--	88%	1	Grignard reagent	--	--	--	0	0
Oxomemazine Hydrochloride	Anti-allergic	Allergy	Chemical Pharmaceuticals	13	511%	4	N-Arylation	--	6.6	2.4	0.35	0
Diacerein	Anti-Gout	Osteoarthritis	Chemical Pharmaceuticals	25	254%	27	Acetalization, Alcohol Oxidation, Biosynthesis, Bromination, Carbonate Synthesis, Carbonyl Oxidation, Carbonyl Reduction, Diazotization, Epoxidation, Fermentation, Fluorination, Grignard Reaction, Iodination, Iodition, Oxidation, Carbonyl-Oxidation, Carbon	--	13.1	61.5	0.03	0
Perindopril	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	10	129%	7	Amine Alkylation, Aminoacid Coupling, Carbonyl Reduction, Catalytic High Pressure Hydrogenation, Chlorination, Cyclization, Dehydration, Esterification, Imine Reduction, Imine Synthesis, N-Alkylation, N-Benzoylation, N-Tosylation, Resolution, Amino Acid Co	2022	--	0	1.69	0.43
Cinnarizine	Anti-histamine	Vertigo, Tinnitus, Nausea And Vomiting Such As That Seen In Meniere'SDisease	Chemical Pharmaceuticals	184	81%	57	Iron-catalyzed cross coupling	--	--	682.1	88.77	2.77
Diclofenac Diethylamine	Pain Management	Anti-Inflammatory, Analgesic	Chemical Pharmaceuticals	255	140%	44	Solid-liquid separation	2017	3.9	971.7	77.93	0
Etofenamate	Pain Management	Musculoskeletal, Joint And Soft Tissue Disorders	Chemical Pharmaceuticals	5	38%	9	Hydrolysis	2003	7.4	64.9	0.68	0.01
Isradipine	Anti-hypertensive	Hypertension, Thiazide-Type Diuretics	Chemical Pharmaceuticals	3	44%	12	Formylation, Hantzsch Pyridine Synthesis, Lithiation, No2-Reduction, Pyridine Synthesis	2003	6.5	0.3	0.01	0
Lornoxicam	Anti-Gout	Rheumatoid Arthritis	Chemical Pharmaceuticals	1	28%	1	--	--	11.6	29.2	0	0
Naratriptan Hydrochloride	Pain Management	Migraine	Chemical Pharmaceuticals	27	748%	15	Bromination, Diazotization	2010	8.3	1.2	0.19	0
Meprednisone	Anti-Gout	Rheumatic Diseases, Dermatological, Gastrointestinal, Respiratory And Ophtalmological	Chemical Pharmaceuticals	1	42%	3	Amine Alkylation, Chlorination	--	--	--	0	0
Acebutolol Hydrochloride	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	8	351%	15	Amidation, Esterification, Fries Rearrangement, O-Alkylation	1990	--	5.9	0.01	0.55
Olopatadine Hydrochloride	Anti-allergic	Seasonal Allergic Rhinitis, Urticaria, Allergic Rhinitis (Ar), Allergic Conjunctivitis	Chemical Pharmaceuticals	77	136%	34	Bromination, Friedel-Crafts Reaction, N-Alkylation, O-Alkylation, Wittig Reaction	2010	5.2	0.8	0.12	0.01
Methyl Prednisolone	Anti-allergic	Blood Disorder, Severe Allergic Reaction, Certain Cancers, Eye Conditions, Skin, Kidney, Intestinal, Lung Disease, And Immune System Disorder	Chemical Pharmaceuticals	121	71%	91	Acetalization, Dehydrogenation, Diels-Alder Reaction, Epoxidation, Grignard Reaction, Esterification, Ketalization	2006	7.3	339.2	1.41	3.01
Dexketoprofen Trometamol	Pain Management	Moderate Pain, Including Dysmenorrhoea, Musculoskeletal Pain And Toothache	Chemical Pharmaceuticals	80	195%	25	Friedel-Crafts Reaction, Resolution	--	6.7	149.6	17.66	0
Ketorolac Tromethamine	Pain Management	Pain	Chemical Pharmaceuticals	355	420%	80	Aromatic Nucleophilic Substitution, Bromination, Cyclopropane Cleavage, Decarboxylation, Enamine Synthesis, Iodination, Mesylation, Vilsmeier-Haack Reaction	2009	8.9	262.2	42.34	0.31
Enalapril	Anti-hypertensive	Hypertension, Heart Failure, Asymptomatic Left Ventricular Dysfunction	Chemical Pharmaceuticals	4	23%	6	Amidation, Amine Alkylation, Butyllithium, Carbonyl Reduction, Cyanohydrin Synthesis, Cyclopropanation, Grignard Reaction, Hydrogenation, Hydrolysis, Jones Oxidation, Oxidation, Reductive Amination, Suzuki Coupling Reaction, Anhydride Synthesis, C-Alkylati	--	--	0	0.03	0.11
Famprofazone	Pain Management	Pain	Chemical Pharmaceuticals	1	24%	--	Mannich reaction/elimination sequence, cyclocondensation, Nucleophilic addition reaction	--	--	--	0	0
Frovatriptan Succinate	Pain Management	Migraine	Chemical Pharmaceuticals	12	102%	13	Cyanation, N-Arylation, Resolution, Carbamate Synthesis, Hydrazine Synthesis, No-Reduction, O-Tosylation	2013	6.6	0.5	0.05	0
Upadacitinib	Anti-Gout	Rheumatoid Arthritis	Chemical Pharmaceuticals	163	218%	103	Acylation, Aryne Synthesis, Bromination, Friedel-Crafts Acylation, Phosgenation, N-Bromination	2030	5.6	0	132.73	37.16
Trichloromethiazide	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	3	7%	6	--	--	--	0	0	0
Celecoxib	Anti-Gout	Osteoarthritis, Ankylosing Spondylitis (As), Acute Gouty Arthritis (Ga), Rheumatoid Arthritis	Chemical Pharmaceuticals	21	81%	22	--	2013	8.4	1642.9	0.26	0.3
Eletriptan	Pain Management	Menstrual Migraine, Migraine	Chemical Pharmaceuticals	5	103%	3	Bromination, Carbonate Synthesis, Co-Reduction, Diazotization, Fermentation, Heck Reaction, Hydrogenation	--	7.6	0	0.17	0.03
Loratadine	Anti-histamine	Allergic Rhinitis, Chronic Urticaria, Allergic Skin Disorders.	Chemical Pharmaceuticals	635	73%	117	Amide Dehydration, Carbamate Synthesis, Carbonyl Reduction, Chlorination, Condensation, Cyanation, Dehalogenation, Dehydration, Dehydroxy-Chlorination, Friedel-Crafts Reaction, Grignard Reaction, Hydrogenation, Hydrolysis, N-Arylation, N-Oxidation, Oxidati	2018	11.8	916.3	116.4	0.32
Prazosin	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	4	424%	1	Cyclization	--	--	0	0.01	0
Morphine Sulfate	Pain Management	Addiction Disorder And Drug Abuse, Pain	Chemical Pharmaceuticals	2	11%	17	Extraction, Concentration,Filtration, Purification & Isolation	2010	8.1	0	0	0.04
Felodipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	28	119%	28	Diazotization, Hantzsch Pyridine Synthesis, Oxidation, Pyridine Synthesis, Diazotation	2001	--	10.3	2.06	0.21
Enalaprilat Dihydrate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	3	98%	1	Amidation, amine alkylation, butylithium, chloropropanation, oxidation	--	--	--	0	0
Urapidil	Anti-hypertensive	Essential Hypertension, Renal Hypertension, Hypertension Associated With Pheochromocytoma. Treatment Of Dysuria Associated With Prostatic Hyperplasia. Treatment Of Dysuria Associated With Neurogenic Bladder.	Chemical Pharmaceuticals	4	41%	3	N-alkylation	--	--	104.3	20.62	0.25
Trimebutine	Pain Management	Irritable Bowel Syndrome pain, Postoperative Paralytic Ileus	Chemical Pharmaceuticals	6	39%	8	Friedel-Crafts Reaction	--	--	11	0	0
Levocetirizine Amide	Anti-histamine	Perennial Allergic Rhinitis And Uncomplicated Skin Manifestations Of Chronic Idiopathic Urticaria	Chemical Pharmaceuticals	5	93%	1	Friedel-Crafts Reaction	--	5.0	0	0.3	0
Nisoldipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	3	69%	10	Bromination, Hantzsch Pyridine Synthesis, Pyridine Synthesis	2012	--	21324	0	0
Doxylamine Succinate	Anti-histamine	Allergies, Antitussive, Emesis, Hypnotic	Chemical Pharmaceuticals	117	35%	42	Bromination	--	--	546.8	6.91	0.94
Cetirizine	Anti-histamine	Seasonal Allergic Rhinitis	Chemical Pharmaceuticals	35	65%	20	Amine Alkylation, Catalytic Hydrogenation, Chlorination, Chlorodehydroxylation, Decarboxylation, Dehalogenation, Double Bond Cleavage, Ester Hydrolysis, Grignard Reaction, Hydrolysis, Jones Oxidation, N-Alkylation, O-Alkylation, Oxidation	2021	3.2	6.2	5.22	0.06
Levocetirizine	Anti-histamine	Seasonal And Perennial Allergic Rhinitis, Chronic Idiopathic Urticaria (Ciu), Allergic Rhinitis (Ar), Prurigo, Skin Pruritus, Dermatitis, Eczema, Hives	Chemical Pharmaceuticals	17	149%	8	Friedel-Crafts Reaction	--	--	5.5	0.15	0.04
Bepotastine	Anti-histamine	Allergic Rhinitis And Uriticaria/Puritus	Chemical Pharmaceuticals	--	243%	1	Friedel-Crafts Acylation	2027	--	0.2	0	0
Chlorpheniramine Maleate	Anti-allergic	Rhinitis, Urticaria, Allergy, Common Cold, Asthma And Hay Fever	Chemical Pharmaceuticals	482	158%	128	Alkylation, hydrolysis and decarboxylation	2003	4.5	1570.2	227.31	0.41
Rizatriptan Benzoate	Pain Management	Migraine	Chemical Pharmaceuticals	83	45%	41	Diazotization, reduction	2012	7.9	551.1	0.4	0
Parecoxib Sodium	Pain Management	Pain	Chemical Pharmaceuticals	4	178%	4	Friedel-Crafts Reaction	--	9.0	0.1	0.02	0
Cloprednol	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	18	528%	30	Amine Alkylation, Bromination, Carbonyl Reduction, Chloromethylation, Friedel-Crafts Reaction, N-Alkylation, O-Acetylation	--	5.1	--	4.48	0
Nalbuphine Hydrochloride	Pain Management	Anaethesia, Pain	Chemical Pharmaceuticals	26	314%	12	Bromination	2025	9.2	0.7	0.17	0.01
Deracoxib	Pain Management	Management ofpainand inflammation associated with OA in dogs (Veterinary)	Chemical Pharmaceuticals	2	202%	3	Oxidation and o-demethylation	2025	--	0.2	0.05	0
Drotaverine	Pain Management	Bowel Disorder And Renal Colic spasm, Pain	Chemical Pharmaceuticals	3	274%	6	Condensation, Cyanation, Amidation, Chloromethylation, Cyclisation, Nitrile Reduction	--	6.5	8.8	1.63	0
Methscopolamine Bromide	Pain Management	Peptic ulcer Pain	Chemical Pharmaceuticals	14	21%	7	Filtration/centrifugation	--	7.4	0.3	0.05	0
Glycopyrrolate	Anti-asthmatic	Chronic Obstructive Pulmonary Disease, Asthma	Chemical Pharmaceuticals	5	68%	10	--	2020	5.6	5.8	0	0.27
Glycopyrronium Bromide	Anti-asthmatic	Chronic Obstructive Pulmonary Disease, Asthma	Chemical Pharmaceuticals	43	118%	24	Reduction reaction, Formylation, Debenzylation, Recrystallization	--	3.7	0.3	0	0
Prednisone Acetate	Anti-allergic	Perennial Or Seasonal Allergic Rhinitis, Exfoliative Dermatitis, Chronic Lymphocytic Leukaemia, Hodgkin'S Or Non-Hodgkin'S Lynphomas	Chemical Pharmaceuticals	2	89%	3	Microbiological dehydrogenation	2015	8.9	0	0.01	0
Ketoprofen Lysinate	Pain Management	Chronic Pain	Chemical Pharmaceuticals	--	202%	1	Dehydrated alcohol crystallization	--	--	--	0	0
Mepryamine Maleate	Anti-allergic	Allergic Conditions, Hypersensitivity Reaction, Pruritic Skin Disorder	Chemical Pharmaceuticals	110	152%	19	Methylation	--	8.3	107.2	0	0
Fenoldopam Mesylate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	31%	1	--	--	--	--	0	0
Roflumilast	Anti-asthmatic	Chronic Obstructive Pulmonary Disease, Asthma	Chemical Pharmaceuticals	36	121%	22	Reduction reaction, Formylation, Debenzylation, Recrystallization	2020	6.5	0	0.13	0.04
Sulfinpyrazone	Anti-Gout	Gout And Gouty Arthritis	Chemical Pharmaceuticals	6	38%	8	Esterification, Phosgenation	--	--	--	9.9	0
Imidapril	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	48%	1	Bromination, Butyllithium, Chlorination, Grignard Reaction, Hydrogenolysis, Reductive Amination, Suzuki Coupling Reaction	2025	--	0	0	0
Nebivolol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	21	135%	14	Alcohol Oxidation, Bromination, Diels-Alder Reaction, Epoxidation, Hydrogenolysis, Oxidation, Friedel-Crafts Reaction, Reduction	--	5.0	0.6	19.18	0.11
Lisinopril	Anti-hypertensive	Hypertension & Hearfailure Therapy	Chemical Pharmaceuticals	99	20%	35	Amide Coupling, Butyllithium, Chromatography, Cyanation, Phosgenation, Reductive Amination	2035	--	355.1	32.42	1.81
Floctafenine	Pain Management	Pain	Chemical Pharmaceuticals	3	121%	1	Friedel-Crafts Reaction	--	5.8	22.1	1.6	0
Carvedilol	Anti-hypertensive	Angina Pectoris, Heart Failure, Hypertension	Chemical Pharmaceuticals	223	137%	93	Amine Alkylation, C=C Hydrogenation, Cyanation, Cyclization, Hydrogenation, Imine Synthesis, N-Alkylation, O-Acetylation, O-Alkylation	2015	--	254.8	32.56	9.27
Alacepril	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	27%	1	Amidation, Epoxidation, Michael Addition, Resolution	--	--	--	0	0
Carbinoxamine Maleate	Anti-histamine	Perennial Allergic Rhinitis, Seasonal Allergic Rhinitis	Chemical Pharmaceuticals	25	122%	14	Williamson ether synthesis	2027	--	233.4	10.85	0
Dimetindene Maleate	Anti-histamine	Ocular Allergies, Allergic Dermatitis, Rhinitis, Urticaria	Chemical Pharmaceuticals	37	368%	9	Friedel-Crafts Acylation, N-Bromination	--	--	0.8	0.08	0
Amlodipine	Anti-hypertensive	Hypertension,Coronary Artery Disease,Chronic Stable Angina,Vasospastic Angina	Chemical Pharmaceuticals	69	58%	52	Bromination, Chlorosulfonation, Diketene Technology, Hantzsch Pyridine Synthesis, Knoevenagel Condensation, Pyridine Synthesis	--	--	54184.5	100.43	0.32
Amlodipine Maleate	Anti-hypertensive	Hypertension And Angina Pectoris	Chemical Pharmaceuticals	34	384%	12	Bromination, Chlorosulfonation, Diketene Technology, Hantzsch Pyridine Synthesis, Knoevenagel Condensation, Pyridine Synthesis	--	--	46.3	2.08	0
Desacetyl Diltiazem Hydrochloride	Anti-hypertensive	Angina, Hypertension	Chemical Pharmaceuticals	3	40%	1	Assymetric reduction, N-alkylation,	--	--	0	0	0
Beclomethasone	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	1	191%	1	Oxidization, quenching, purification	--	7.1	0	0.04	0.04
Clocortolone	Anti-allergic	Anti-Inflammatory And Pruritic (Itching)	Chemical Pharmaceuticals	--	242%	1	--	--	7.5	--	0	0
Sumatriptan Succinate	Pain Management	Migraine, Cluster Headaches	Chemical Pharmaceuticals	151	888%	52	Fischer indole synthesis	2014	7.2	89	8.05	0.06
Eplerenone	Anti-hypertensive	Hypertension, Congestive Heart Failure	Chemical Pharmaceuticals	48	108%	24	Amination, Dehydrogenation, Diels-Alder Reaction, Epoxidation, Grignard Reaction, Hydrogenation, Hydroxylation, Oppenauer Oxidation, Oxidation, Biosynthesis, C=C-Hydrogenation, Carbonyl-Oxidation	2019	--	110.9	1.41	0.74
Diltiazem	Anti-hypertensive	Hypertension, Atrial Fibrillation Or Atrial Flutter, Rapid Ventricular Rate	Chemical Pharmaceuticals	9	47%	22	Amidation, Amine Alkylation, Carbonate Synthesis, Carbonyl Reduction, Condensation, C-Oxidation, Darzens Condensation, Darzens Condensation Reaction, Enantioselective Carbonyl Reduction, Enzymatic Co Reduction (Biotechnology), N-Alkylation, Oxidation, Reso	--	--	13.3	15.17	0
Thiocolchicine	Pain Management	Neoplasms, acute low back pain & other musculoskeletal painful and inflammation	Biotech & Biochemicals	4	91%	1	Desulfurization	--	--	0	0	0
Salmeterol	Anti-asthmatic	Asthma, Bronchitis	Chemical Pharmaceuticals	52	33%	18	Fermentation, bromination, esterification	--	6.5	0	0	0
Acemetacin	Anti-Gout	Arthritis, Pain	Chemical Pharmaceuticals	14	127%	15	Bromination, Dehydration, Dehydrogenation, Epoxidation, Fluorination	2004	9.2	0.4	0.08	1.37
Celiprolol Hydrochloride	Anti-hypertensive	Mild To Moderate Hypertension And Effort-Induced Angina Pectoris	Chemical Pharmaceuticals	6	33%	7	Hydrolysis, actylation, reduction, acylation	--	6.3	10.2	0	0.84
Rupatadine	Anti-allergic	Chronic Urticaria, Allergic Rhinitis	Chemical Pharmaceuticals	4	50%	1	Amide Dehydration, Amine Alkylation, Bromination, Butyllithium, Carbamate Synthesis, Carbonyl Reduction, Chlorination, Condensation, C-Oxidation, Cyanation, Dehydration, Dehydroxy-Chlorination, Formylation, Friedel-Crafts Reaction, Grignard Reaction, N-Alk	--	6.7	0	0.13	0
Ramipril	Anti-hypertensive	Diabetic Nephropathies, Heart Failure, Hypertension	Chemical Pharmaceuticals	171	69%	61	Acylation, Amidation, Amine Alkylation, Anhydride Synthesis, C-Alkylation, Chlorination, Coupling Reaction, Enamine Synthesis, Esterification, Friedel-Crafts Acylation, Hydrogenolysis, Imine Synthesis, N-Acetylation, N-Alkylation, Nitro-Reduction, Resoluti	2012	--	309.3	17.79	5.64
Spironolactone	Anti-hypertensive	Antihypertensive, Antihyperaldosteronism, Cardioprotectant	Chemical Pharmaceuticals	89	421%	58	C=C Hydrogenation, C-Alkylation, Carbonyl Oxidation, Cc-Dehydrogenation, Dehydrogenation, Grignard Reaction, Michael Addition, Oppenauer Oxidation, Oxidation, S-Alkylation, Triple Bond Hydrogenation	2036	--	457.3	0.1	61.48
Cilazapril	Anti-hypertensive	Hypertension And Heart Failure	Chemical Pharmaceuticals	28	335%	10	Amide Reduction, Amide Reductive Cleavage, Bromination, Carbonate Synthesis, Diels-Alder Reaction, Hydrogenation, N-Nitrosation, Phosgenation, Resolution	--	--	7.5	0.57	0.01
Azelastine Hydrochloride	Anti-histamine	Allergic Rhinitis, Allergic Conjunctivitis, Vasomotor Rhinitis	Chemical Pharmaceuticals	39	724%	26	Decarboxylation, Friedel-Crafts Reaction	2010	7.6	0.9	0.07	0.08
Maxacalcitol	Vitamin	Secondary Hyperparathyroidism, Psoriasis	Chemical Pharmaceuticals	--	--	1	Alcohol Oxidation, Bromination, Carbonyl Reduction, Chlorination, Diels-Alder Reaction, Elimination, Epoxidation, Fermentation, Grignard Reaction, Hydroboration, Michael Addition, Oxidation, Wittig Reaction	--	8.3	--	0	0
Loratadine Hydrochloride	Anti-histamine	Allergic Rhinitis, Chronic Urticaria, Allergic Skin Disorders.	Chemical Pharmaceuticals	1	213%	1	Amide Dehydration, Carbamate Synthesis, Carbonyl Reduction, Chlorination, Condensation, Cyanation, Dehalogenation, Dehydration, Dehydroxy-Chlorination, Friedel-Crafts Reaction, Grignard Reaction, Hydrogenation, Hydrolysis, N-Arylation, N-Oxidation, Oxidati	--	1.0	0	0.24	0
Prazosin Hydrochloride	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	11	534%	19	Cyclization	1987	--	0.3	0.26	0.04
Flupirtine Maleate	Pain Management	Fibromyalgia	Chemical Pharmaceuticals	10	757%	10	Phosgenation	--	8.1	66.1	0.4	0
Beraprost Sodium	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	191%	4	Nitration, nutralization, deprotection reaction	--	--	--	0	0
Bendroflumethiazide	Anti-hypertensive	Hypertension And Edema Related To Heart Failure	Chemical Pharmaceuticals	17	136%	11	--	--	--	9.5	1.38	0
Bamifylline Hydrochloride	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	--	--	1	--	--	5.3	18.8	0	0
Losartan	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	15	39%	5	Boric Acid Synthesis, Bromination, Carbonyl Reduction, Chlorination, Grignard Reaction, Imidazole Synthesis, Lithiation, Negishi Coupling, Pinner Reaction, Stille Coupling, Suzuki Coupling Reaction, Tetrazole Synthesis, Vilsmeier-Haack Reaction	--	--	74.1	22.75	0.62
Terazosin Hydrochloride	Anti-hypertensive	Benign Prostatic Hyperplasia, Hypertension	Chemical Pharmaceuticals	28	57%	25	Amination, Chlorination, Nitration, Reduction	2010	--	1.8	0.25	0
Urapidil Hydrochloride	Anti-hypertensive	Essential Hypertension, Renal Hypertension, Hypertension Associated With Pheochromocytoma. Treatment Of Dysuria Associated With Prostatic Hyperplasia. Treatment Of Dysuria Associated With Neurogenic Bladder.	Chemical Pharmaceuticals	2	131%	1	N-alkylation	--	--	2.2	0.49	0
Benazepril	Anti-hypertensive	Hypertension, Congestive Heart Failure, Chronic Renal Failure	Chemical Pharmaceuticals	4	64%	4	Amidation, Amine Alkylation, Beckmann Rearrangement, Biosynthesis, Claisen Condensation, Nitration, Resolution, Strecker Synthesis, Amination, Bromination, Friedel-Crafts Reaction, Imine Reduction, Imine Synthesis, N-Acetylation, N-Alkylation, Strecker Ami	--	--	1	0.2	0.02
Ketotifen Fumarate	Anti-Allergic	Eye Allergy	Chemical Pharmaceuticals	23	140%	25	Bromination, Carbonate Synthesis, Carbonyl Reduction, Chlorination, Condensation, Cyclization, Friedel-Crafts Reaction, Grignard Reaction, Perkin Condensation Reaction	--	5.3	0.7	0.1	0
Epithiazide	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	93%	--	Alkylation, condensation	--	--	0.1	0	0
Reproterol Hydrochloride	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	9	81%	22	Hydrogenation	--	5.6	--	0	0
Oxatomide	Anti-asthmatic	Antiallergic, Antiasthmatic	Chemical Pharmaceuticals	5	276%	6	Alcohol Oxidation, Biosynthesis, Bromination, Carbonate Synthesis, Carbonyl Oxidation, Carbonyl Reduction, Catalytic Hydrogenation, Chlorination, Diazotization, Elimination, Epoxidation, Iodination, Iodition, Ketalization, O-Alkylation, Oxidation	--	4.2	7.1	0.31	0.02
Flavoxate Hydrochloride	Pain Management	Bladder And Urinary Tract Symptoms, Helps To Reduce Leaking Of Urine, Feelings Of Needing To Urinate Right Away, Frequent Trips To The Bathroom, Bladder Pain	Chemical Pharmaceuticals	39	538%	25	Friedel-Crafts Reaction	--	6.6	145.9	5.91	11.53
Irbesartan	Anti-hypertensive	Hypertension, Diabetic Nephropathy	Chemical Pharmaceuticals	159	44%	101	Amidation, Azide Reduction, Azide Synthesis, Biphenyl Synthesis, Boric Acid Synthesis, Bromination, Cyclization, Grignard Reaction, Imidate Synthesis, N-Alkylation, N-Methylation, O-Methylation, Oxazoline Synthesis, Suzuki Coupling Reaction, Tetrazole Synt	2011	6.7	1034.7	140.42	33.38
Ephedrine Sulfate	Anti-asthmatic	Bronchial Asthma	Chemical Pharmaceuticals	37	56%	10	Friedel-Crafts reaction	--	6.0	13.8	1.88	0.02
Pizotifen Malate	Pain Management	Migraines	Chemical Pharmaceuticals	4	65%	1	Grignard coupling	--	4.7	0	0	0
Budesonide	Anti-asthmatic	Crohn Disease,Ulcerative Colitis, Asthma	Chemical Pharmaceuticals	15	282%	8	Bromination, Diazotization	2010	5.0	21.9	0.3	0
Trandolapril	Anti-hypertensive	Hypertension, Heart Failure	Chemical Pharmaceuticals	12	90%	18	Adol Condensation Reaction, Aminoacid Coupling, Chlorination, Chromatography, Esterification, Favorskii Rearrangement, Hydrogenolysis, Michael Addition, Suzuki Coupling Reaction	2015	--	1.2	0.25	0.08
Mizolastine	Anti-histamine	Allergic Conjunctivitis, Allergic Rhinitis	Chemical Pharmaceuticals	2	652%	2	Chlorination, Deoxo-Chlorination, Fischer Indole Synthesis, N-Benzylation, Pyrimidine Amination	--	--	0	0.09	0
Buclizine	Anti-histamine	Nausea, Vomiting, Dizziness Associated With Motion Sickness And Vertigo (Dizziness Caused By Other Medical Problems)	Chemical Pharmaceuticals	1	225%	1	Friedel-Crafts Reaction	2027	--	0.2	0.08	0
Drotaverine Hydrochloride	Pain Management	Bowel Disorder And Renal Colic spasm, Pain	Chemical Pharmaceuticals	145	16%	61	Amidation, Chloromethylation, Cyanation, Cyclisation, Nitrile Reduction	2031	6.6	438	28.01	0.12
Betamethasone Acetate	Anti-Gout	Atopic Dermatitis, Rheumatoid Arthritis	Chemical Pharmaceuticals	--	--	--	--	--	11.5	0.5	0	0
Flunisolide	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	49	17%	18	Bromination	2006	7.2	0.1	90.77	0.75
Triamcinolone Acetonide	Anti-allergic	Eczema, Dermatitis, Allergies	Chemical Pharmaceuticals	147	49%	67	Bromination, Dehydration, Dehydrogenation, Epoxidation, Fluorination	2016	2.7	15.1	1.45	0.46
Brompheniramine Maleate	Anti-histamine	Common Cold And Allergic Rhinitis	Chemical Pharmaceuticals	70	471%	18	Bromination, Decarboxylation, Deprotonation, Heteroaromatic Nucleophilic Substitution, High Temperature	--	--	33	2.61	0.12
Dexbrompheniramine Maleate	Anti-allergic	Allergies, Hay Fever, Colds	Chemical Pharmaceuticals	55	44%	14	Bromination	--	8.7	18.4	0.02	0
Valsartan	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	298	58%	128	Amidation, Azidation, Bromination, Carbonate Synthesis, Grignard Reaction, Hydrogenolysis, Hydrolysis, Imine Reduction, Imine Synthesis, N-Alkylation, Suzuki Coupling Reaction	2012	--	2484	266.77	75.51
Quinapril	Anti-hypertensive	Heart Failure, Hypertension, Myocardial Ischaemia	Chemical Pharmaceuticals	3	181%	4	Amidation, Amine Alkylation, Anhydride Synthesis, C-Alkylation, Coupling Reaction, Decarboxylation, Diastereoisomer Separation, Esterification, Fischer Indole Synthesis, Grignard Reaction, Hydrogenolysis, N-Alkylation, Reductive Amination, Silylation, Suzu	--	--	1.9	0	0
Candesartan	Anti-hypertensive	Hypertension, Lowering High Blood Pressure Helps Prevent Strokes, Heart Attacks, And Kidney Problems	Chemical Pharmaceuticals	17	301%	8	Esterification reaction, reduction reaction, carbalkoxylation reaction, nitration reaction, N-alkylation reaction, catalytic hydrogenation reaction, cyclization reaction, hydrolysis reaction, condensation reaction and de-protection reaction.	--	--	9.1	1.89	0.7
Bisoprolol Fumarate	Anti-hypertensive	Hypertension, Heart Failure, Atrial Fibrillation, Angina Pectoris	Chemical Pharmaceuticals	317	424%	90	Amine Alkylation, Carbonate Synthesis, Carbonyl Reduction, Catalytic Hydrogenation, Chlorination, Chloromethylation, Hydrolysis, N-Alkylation, O-Alkylation, Sodium Borohydride Reduction	2000	--	280.7	15.69	1.62
Lisinopril Dihydrate	Anti-hypertensive	Hypertension & Hearfailure Therapy	Chemical Pharmaceuticals	73	23%	31	Amide Coupling, Butyllithium, Chromatography, Cyanation, Phosgenation, Reductive Amination	--	--	113.9	7.95	1.19
Perindopril-Tert-Butylamine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	112	171%	35	--	2009	6.8	38.5	4.68	0.14
Imidapril Hydrochloride	Anti-hypertensive	Essential Hypertension	Chemical Pharmaceuticals	6	84%	9	Amide Coupling, Bromination, Dehydroxy-Chlorination, Grignard Reaction, Hoffmann Reaction, Hydrogenolysis, Reductive Amination, Tert-Butylation	2027	5.8	0.3	0	0.02
Olmesartan	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	7	332%	9	Rearrangement reaction, substitution reaction, underpressure distillation	--	5.0	1	2.78	0.01
Diltiazem Hydrochloride	Anti-hypertensive	Hypertension, Atrial Fibrillation Or Atrial Flutter, Rapid Ventricular Rate	Chemical Pharmaceuticals	181	41%	64	Amidation, Carbonyl Reduction, C-Oxidation, Darzens Condensation Reaction, Enantioselective Carbonyl Reduction, Enzymatic Co Reduction (Biotechnology), N-Alkylation, Resolution, S-Alkylation	2011	--	2137.5	194.35	8.21
Lacidipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	7	333%	9	Hantzsch Pyridine Synthesis, Pyridine Synthesis	--	5.3	2.5	0.09	0.01
Clevidipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	41%	3	Hantzsch Pyridine Synthesis, Pyridine Synthesis	2021	--	0	0	0
Clevidipine Butyrate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	35%	4	Hantzsch Pyridine Synthesis	2015	--	0	0	0
Azilsartan	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	2	86%	4	Arylation, Biosynthesis, Bromination, Suzuki Coupling Reaction	2031	--	0	0.02	0
Carbasalate Calcium	Pain Management	Headache, Fever And Pain	Chemical Pharmaceuticals	1	220%	3	Adularescent precipitation	--	--	2.3	0	0
Terazosin Hydrochloride Dihydrate	Anti-hypertensive	Benign Prostatic Hyperplasia, Hypertension	Chemical Pharmaceuticals	3	23%	17	Amination, Chlorination, Nitration, Reduction	2014	--	0	0	0
Clemastine Fumarate	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	1	129%	4	Friedel-Crafts Reaction	--	--	0	0	0
Apremilast	Anti-Gout	Psoriasis, Psoriatic Arthritis	Chemical Pharmaceuticals	129	167%	91	Acetalization, Alcohol Oxidation, Biosynthesis, Bromination, Carbonate Synthesis, Carbonyl Oxidation, Carbonyl Reduction, Diazotization, Epoxidation, Fermentation, Fluorination, Grignard Reaction, Iodination, Iodition, Oxidation, Carbonyl-Oxidation, Carbon	2023	11.1	1.2	4.85	17.69
Thiamine Pyrophosphate	Vitamin	Alcoholism,Cirrhosis,Stomach/Intestinal Problems	Biotech & Biochemicals	1	50%	--	Fementation	--	--	--	0.02	0
Benazepril Hydrochloride	Anti-hypertensive	Hypertension, Congestive Heart Failure, Chronic Renal Failure	Chemical Pharmaceuticals	55	139%	31	Amidation, Amination, Beckmann Rearrangement, Bromination, Friedel-Crafts Reaction, Imine Reduction, Imine Synthesis, N-Acetylation, N-Alkylation, Nitration, Resolution, Strecker Amino Acid Synthesis	2003	--	512.1	1.5	1.28
Losartan Potassium	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	445	25%	168	Boric Acid Synthesis, Bromination, Carbonyl Reduction, Chlorination, Grignard Reaction, Lithiation, Negishi Coupling, Pinner Reaction, Stille Coupling, Suzuki Coupling Reaction, Tetrazole Synthesis, Vilsmeier-Haack Reaction	2009	--	3846.4	570.58	69.7
Orphenadrine Citrate	Pain Management	Pain	Chemical Pharmaceuticals	137	227%	28	Friedel-Crafts Reaction	--	7.6	575.5	101.9	5.73
Cetirizine Hydrochloride	Anti-histamine	Seasonal Allergic Rhinitis	Chemical Pharmaceuticals	662	75%	194	Amine alkylation, catalytic Hydrogenation, Chlorination, Chlorodehydroxylation, Decarboxylation	2016	3.2	796	10.12	0.06
Levocetirizine Dihydrochloride	Anti-histamine	Seasonal And Perennial Allergic Rhinitis, Chronic Idiopathic Urticaria (Ciu), Allergic Rhinitis (Ar), Prurigo, Skin Pruritus, Dermatitis, Eczema, Hives	Chemical Pharmaceuticals	307	54%	84	Friedel-Crafts Reaction	2012	--	52.1	0.7	0
Eletriptan Hydrobromide	Pain Management	Migraine	Chemical Pharmaceuticals	31	100%	20	Bromination, Carbonate Synthesis, Co-Reduction, Diazotization, Fermentation, Heck Reaction, Hydrogenation	2016	7.4	2.4	0.47	0.01
Bilastine	Anti-allergic	Chronic Idiopathic Urticaria (Ciu), Allergic Conjunctivitis	Chemical Pharmaceuticals	53	111%	22	Amidation, Amine Alkylation, Biosynthesis, Bromination, C-Alkylation, C-Arylation, Catalytic Hydrogenation, Chlorination, Condensation, Cyanation, Dehydration, Diazotization, Hydroxymethylation, Lithiation, N-Alkylation, N-Arylation, No-Reduction	--	7.2	186.7	20.47	0.2
Benfotiamine	Vitamin	Dietary supplement to treat diabetic neuropathy	Chemical Pharmaceuticals	47	83%	37	Amelioration	--	8.0	257.7	35.75	0.43
Almotriptan Malate	Pain Management	Pain	Chemical Pharmaceuticals	18	68%	10	Amine Alkylation, Bromination, Catalytic Hydrogenation, Condensation, Dehydration, Fermentation, Fischer Indole Synthesis, Hydrogenation, Nitration, Rosenmund Reaction, Sulfonamidation, Chlorination, Dechlorocyanation, Deoximation, Diazonium Reduction, Dia	2015	3.1	0.7	0.08	0
Ebastine	Anti-histamine	Allergic Conjunctivitis, Allergic Rhinitis, Urticaria	Chemical Pharmaceuticals	88	471%	22	Acylation, Chlorination, Friedel-Crafts Acylation, Dehydroxy-Chlorination, N-Bromination	--	--	15.6	3.65	0
Terfenadine	Anti-histamine	Allergic Rhinitis, Hay Fever, And Allergic Skin Disorder	Chemical Pharmaceuticals	2	241%	15	Friedel-Crafts Reaction	--	--	1.8	0	0
Tiotropium Bromide	Anti-asthmatic	Chronic Obstructive Pulmonary Disease, Asthma	Chemical Pharmaceuticals	1	574%	5	Bromination, Carbonyl Oxidation, Carbonyl Reduction, Chlorination, Elimination, Epoxidation, Iodination, Ketalization, O-Alkylation	2020	5.3	0.5	0	0
Methyl Prednisolone Hemisuccinate	Anti-allergic	Blood Disorder, Severe Allergic Reaction, Certain Cancers, Eye Conditions, Skin, Kidney, Intestinal, Lung Disease, And Immune System Disorder	Chemical Pharmaceuticals	21	157%	22	Dehydrogenation, Diels-Alder Reaction, Epoxidation, Esterification, Grignard Reaction, Ketalization	2035	7.6	22.9	1.72	0.13
Quinapril Hydrochloride	Anti-hypertensive	Heart Failure, Hypertension, Myocardial Ischaemia	Chemical Pharmaceuticals	8	43%	18	Amidation, Anhydride Synthesis, C-Alkylation, Coupling Reaction, Decarboxylation, Diastereoisomer Separation, Esterification, Grignard Reaction, Hydrogenolysis, N-Alkylation, Reductive Amination, Silylation	2014	--	19.2	1.3	0.53
Flunarizine Dihydrochloride	Pain Management	Vertigo, Migrain	Chemical Pharmaceuticals	80	59%	23	Friedel-Crafts Reaction	--	5.9	37.2	4.79	0.02
Butorphanol Tartrate	Pain Management	NarcoticPainReliever	Chemical Pharmaceuticals	2	66%	10	Friedel-Crafts Acylation, Carbonyl-Reduction, Cnitro-Reduction, Knoevenagel Condensation, O-Demethylation, N-Bromination	1991	1.5	0	0	0
Diflucortolone Valerate	Anti-allergic	Inflammation And Itching	Chemical Pharmaceuticals	1	359%	4	Acylation, Diazotization, Epoxidation, Fluorination	--	8.5	0	0	0
Nicardipine	Anti-hypertensive	Angina Pectoris, Hypertension	Chemical Pharmaceuticals	2	108%	2	Amination, Amine Alkylation, Fischer Indole Synthesis, Hantzsch Pyridine Synthesis, N-Alkylation, Pyridine Synthesis	--	--	26.1	0.67	0
Pranlukast	Anti-histamine	Allergic Rhinitis, Asthma	Chemical Pharmaceuticals	1	334%	1	Acylation, Bromination, Friedel-Crafts Acylation	--	--	2.4	0.62	0.3
Iloprost Tromethamine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	143%	1	Isolation	--	--	--	0	0
Delapril Hydrochloride	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	1	301%	2	--	--	6.0	0.1	0.01	0
Tiotropium Bromide Monohydrate	Anti-asthmatic	Chronic Obstructive Pulmonary Disease, Asthma	Chemical Pharmaceuticals	10	124%	14	Aromatic Hydrogenation, Biosynthesis, Bromination, Claisen Condensation, Hydrogenation, Hydroxylation, N-Acetylation, No-Reduction, Reductive Amination	2012	4.9	0	121.2	0.31
Flunixin Meglumine	Pain Management	Pain & Fever	Veterinary Active	18	106%	18	Methylation, hydrolysis	--	6.5	24.6	1.78	4.43
Enalapril Maleate	Anti-hypertensive	Hypertension, Diuretics	Chemical Pharmaceuticals	109	28%	50	Amidation, Anhydride Synthesis, C-Alkylation, Catalytic Hydrogenation, Coupling Reaction, Cyanohydrin Synthesis, Decarboxylation, Deprotection, Diastereoisomer Separation, Grignard Reaction, Hydrolysis, Jones Oxidation, Reductive Amination, Silylation	2032	--	189.4	9.86	8.3
Cilnidipine	Anti-hypertensive	Hypertension, Diabetes And Albuminuria	Chemical Pharmaceuticals	8	132%	12	Azeotropic Distillation, Esterification, Hantzsch Pyridine Synthesis, Pyridine Synthesis, Transesterification	--	19.5	0.1	0.57	0
Isometheptene Mucate	Pain Management	Migraines, Headaches	Chemical Pharmaceuticals	--	171%	1	--	--	--	0	0	0
Methyl Prednisolone Sodium Succinate	Anti-allergic	Blood Disorder, Severe Allergic Reaction, Certain Cancers, Eye Conditions, Skin, Kidney, Intestinal, Lung Disease, And Immune System Disorder	Chemical Pharmaceuticals	59	423%	25	Dehydrogenation, Epoxidation, Esterification, Grignard Reaction, Ketalization	--	8.4	13	0.64	0.49
Moexipril	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	359%	2	Fischer Indole Synthesis, Reductive Amination, Resolution	--	--	--	0	0
Pyrathiazine Theoclate	Anti-histamine	Antibacterial, Antibacterial (Veterinary)	Chemical Pharmaceuticals	17	46%	9	--	--	--	17.7	0.09	0
Fluticasone Propionate	Anti-allergic	Nasal Polyps, Rhinitis	Chemical Pharmaceuticals	228	186%	91	Decarboxylation, Dehydration, Diels-Alder Reaction, Epoxidation, Esterification, Fluorination, Grignard Reaction, Iodition, Pyridine Synthesis, Urea Synthesis, Bromination, Chlorination, Dehydrohalogenation, Fermentation (Biotechnology), Grignard Conjugate	2011	9.5	9.3	0.99	0.03
Fexofenadine	Anti-histamine	Seasonal Allergic Rhinitis, Chronic Idiopathic Urticaria (Ciu), Atopic Dermatitis, Skin Pruritus, Dermatitis, Eczema	Chemical Pharmaceuticals	25	819%	24	Amine Alkylation, Carbonate Synthesis, Chlorination, Esterification, Grignard Reaction, Hydrogenation, Hydrolysis, Carbonyl-Reduction, Cyclopropane Chlorination, Ester Hydrolysis, Friedel-Crafts Reaction, Koch-Haaf Carboxylation, N-Alkylation, Pressure Hyd	--	--	93.3	12.7	0.02
Trimebutine Maleate	Pain Management	Irritable Bowel Syndrome pain	Chemical Pharmaceuticals	34	41%	38	Enzymatic biotechnology	--	4.1	218.2	0.09	1.39
Benidipine	Anti-hypertensive	Hypertension, Renoparenchymal Hypertension And Angina Pectoris	Chemical Pharmaceuticals	--	29%	1	Amine Alkylation, Carbonyl Reduction, Chlorosulfonation, Hantzsch Pyridine Synthesis, Hydrogenation, Knoevenagel Condensation, Pyridine Synthesis	--	--	0	0	0
Buclizine Hydrochloride	Anti-histamine	Antiemetic, Antihistaminic	Chemical Pharmaceuticals	32	158%	14	Friedel-Crafts Reaction	--	--	29	5.99	0.23
Nalfurafine Hydrochloride	Anti-histamine	Itching, Pruritus	Chemical Pharmaceuticals	--	63%	2	Catalytic hydrogenation, Reflux reaction,	2035	--	--	0	0
Temocapril Hydrochloride	Anti-hypertensive	Hypertension And Congestive Heart Failure, Diabetic Nephropathy	Chemical Pharmaceuticals	--	--	2	--	--	--	--	0	0
Telmisartan	Anti-hypertensive	Cardiovascular Risk Reduction, Stroke, Hypertension	Chemical Pharmaceuticals	363	120%	206	Azidation, Bromination, Grignard Reaction, Suzuki Coupling Reaction	2014	1.4	1070	65.17	9.1
Nicardipine Hydrochloride	Anti-hypertensive	Angina Pectoris, Hypertension	Chemical Pharmaceuticals	16	206%	24	Amination, Amine Alkylation, Fischer Indole Synthesis, Hantzsch Pyridine Synthesis, N-Alkylation, Pyridine Synthesis	2009	--	31.6	4.6	1.27
Nattokinase	Anti-hypertensive	Hypertension, Angina, Deep Vein Thrombosis	Biotech & Biochemicals	8	--	12	Fermentation, purification technique	--	7.0	1	0	0
Benziodarone	Anti-Gout	Gout	Chemical Pharmaceuticals	--	--	--	Fermentation	--	13.1	0	0	0
Orciprenaline Sulfate	Anti-asthmatic	Bronchospasm, Chronic Bronchitis, Asthma, And Emphysema	Chemical Pharmaceuticals	22	79%	19	Acylation, Chlorination, N-Acylation, Nitration, N-Oxidation, O-Alkylation, Oxidation, Reduction	--	5.0	2.5	0	0
Mometasone Furoate	Anti-histamine	Allergic Rhinitis, Asthma, Nasal Polyps, Perennial Allergic Rhinitis	Chemical Pharmaceuticals	238	80%	90	Alcohol Oxidation, Bromination, Carbonyl Oxidation, Chlorination, Dehydrobromination, Diels-Alder Reaction, Enzymatic Hydroxylation (Biotechnology), Epoxidation, Esterification, Grignard 1-4 Addition, Grignard Reaction, Hydrogenation, Hydroxylation, Oxidat	2012	--	9.6	1.05	0.13
Mometasone Furoate Monohydrate	Anti-histamine	Allergic Rhinitis, Asthma, Nasal Polyps, Perennial Allergic Rhinitis	Chemical Pharmaceuticals	62	178%	24	Alcohol Oxidation, Bromination, Carbonyl Oxidation, Chlorination, Dehydrobromination, Diels-Alder Reaction, Enzymatic Hydroxylation (Biotechnology), Epoxidation, Esterification, Grignard 1-4 Addition, Grignard Reaction, Hydrogenation, Hydroxylation, Oxidat	2014	--	89.1	0.19	0
Carvedilol Phosphate	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	7	26%	13	Amine alkylation, hydrogenation, cyanation, cyclization, hydrogenation	2015	--	0.8	0.05	0.13
Fenoprofen Calcium	Pain Management	Pain	Chemical Pharmaceuticals	6	152%	11	Friedel-Crafts Reaction\No-Arylation\Nbromination	1988	5.5	9.7	2.08	0
Sitagliptin Phosphate Monohydrate	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes	Chemical Pharmaceuticals	156	312%	71	Acylation, Amine Alkylation, Aminoacid Coupling, Arndt-Eistert Homologation, Arndt-Eistert Synthesis, Asymmetric Amination, Asymmetric Hydrogenation, C=C Hydrogenation, C-Alkylation, Carbonyl Reduction, Chlorination, Condensation, C-Oxidation, Cyclization,	--	--	114.7	3.96	0.59
Barnidipine Hydrochloride	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	28%	1	--	2035	--	0.00003	0	0
Fentanyl Citrate	Pain Management	Cancer Related Pain	Chemical Pharmaceuticals	10	44%	26	Precipitation and recrystallization, alkylation, quenched	2016	5.7	0	0	0
Rupatadine Fumarate	Anti-histamine	Chronic Urticaria, Allergic Rhinitis	Chemical Pharmaceuticals	55	337%	18	Reduction reaction, charcolization	2032	5.9	5.2	2.43	0
Fexofenadine Hydrochloride	Anti-histamine	Seasonal Allergic Rhinitis, Chronic Idiopathic Urticaria (Ciu), Atopic Dermatitis, Skin Pruritus, Dermatitis, Eczema	Chemical Pharmaceuticals	444	754%	126	Carbonyl-Reduction, Cyclopropane Chlorination, Ester Hydrolysis, Esterification, Friedel-Crafts Reaction, Grignard Reaction, Koch-Haaf Carboxylation, N-Alkylation, Pressure Hydrogenation	2012	--	1422.6	177.89	0.94
Fluticasone Furoate	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	36	80%	31	Bromination, Carbonyl Oxidation, Chlorination, Decarboxylation, Dehydration, Dehydrohalogenation, Diels-Alder Reaction, Epoxidation, Esterification, Fermentation (Biotechnology), Fluorination, Grignard 1-4 Addition, Iodination, Iodition, Oxidation, S-Alkyl	2021	--	0	0.01	0
Beclomethasone Dipropionate Monohydrate	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	--	17%	1	Chloromethylation	--	5.9	0.2	0	0
Ciclesonide	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	101	157%	39	Condensation, reduction, debenzylating, Quenching, precipitation	2010	1.9	0.1	0.14	0.02
Lomerizine Dihydrochloride	Pain Management	Migraine	Chemical Pharmaceuticals	1	150%	1	Reduction, chlorination, reductive amination	--	--	--	0	0
Lomerizine Hydrochloride	Pain Management	Migraine	Chemical Pharmaceuticals	--	150%	1	Reduction, chlorination, reductive amination	--	--	--	0	0
Domperidone Maleate	Pain Management	Dyspepsia, Heartburn, Epigastric Pain, Nausea, And Vomiting	Chemical Pharmaceuticals	242	123%	65	Chlorination, N-Arylation, Nitration, Nitro-Reduction, Phosgenation	--	6.6	220.4	40.03	0.16
Benidipine Hydrochloride	Anti-hypertensive	Hypertension, Renoparenchymal Hypertension And Angina Pectoris	Chemical Pharmaceuticals	--	88%	1	Amine alkylation, carbonyl reduction, chlorosulfonation, Hantzsch Pyridine Synthesis, Hydrogenation	--	--	0	0	0
Ketanserin Tartrate	Anti-hypertensive	Hypertension,Wounds, Burns, Ulcers And Anal Fissure	Chemical Pharmaceuticals	2	--	1	--	--	--	0	0	0
Bepotastine Besylate	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	7	367%	10	Friedel-Crafts Acylation, N-Bromination	2023	12.5	0.1	0.04	0
Doxazosin Mesylate	Anti-hypertensive	Benign Prostatic Hyperplasia, Hypertension	Chemical Pharmaceuticals	138	754%	61	Aldehyde Oxidation, Chlorination, High Pressure Amination, Nitrationitro-Reduction	2000	--	50.4	5.98	0.18
Ubrogepant	Pain Management	Migraine	Chemical Pharmaceuticals	7	32%	20	Enzyme-mediated dynamic kinetic transamination	2031	--	--	0	0
Olmesartan Medoxomil	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	182	266%	115	Azide Synthesis, Bromination, Chlorination, Grignard Reaction, Imidazole Synthesis, Phosgenation, Suzuki Coupling Reaction	2016	6.1	231.7	30.8	6
Thiocolchicoside	Anti-Gout	Orthopedic, Traumatic And Rheumatologic Disorder	Chemical Pharmaceuticals	133	11%	70	Amination, Bromination, Condensation, Diazotization, Fluorination, Hydrolysis, Nitration, Thiazole Synthesis, Cyanation, Diazotation, Formylation, O-Alkylation, Oximation	2015	12.6	30.6	13.6	1.65
Fosinopril	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	2	70%	2	Amidation, Bromination, Butyllithium, C=C Hydrogenation, Carbonate Synthesis, Carbonyl Reduction, Catalytic Hydrogenation, Decarboxylation, Dehydration, Enzymatic Resolution (Biotechnology), Ester Hydrolysis, Formylation, Grignard Coupling, Grignard Reacti	2023	--	0	0.18	0
Amlodipine Besylate	Anti-hypertensive	Hypertension, Coronary Artery Disease, Angina Pectoris	Chemical Pharmaceuticals	1039	41%	267	Diketene Technology, Hantzsch Pyridine Synthesis, Knoevenagel Condensation	2022	--	2676.4	288.51	2.26
Azilsartan Medoxomil	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	86%	6	Azidation, Biosynthesis, Bromination, Catalytic Hydrogenation, Chlorination, Cyclization, Epoxidation, Esterification, Hydrolysis, N-Alkylation, Nitro Reduction, Nitro-Reduction, Oxadiazole Synthesis, Suzuki Coupling Reaction, Transesterification, Yamaguch	2031	--	0	0.15	0
Zafirlukast	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	416	237%	94	Amine alkylation, bromination, carbonyl Reduction, Chloromethylation, Friedel-Crafts Reaction	2010	4.7	2.1	54.28	0.04
Salbutamol Sulphate	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	--	68%	1	--	2024	6.0	615.7	68.74	0.04
Azelnidipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	16%	10	Amine Alkylation, Epoxidation, Esterification, Hantzsch Pyridine Synthesis, N-Alkylation, Pyridine Synthesis, Transesterification	--	--	0	0	0
Dihydroergotamine	Pain Management	Migraine	Chemical Pharmaceuticals	4	168%	--	Reduction (hydrogenation)	--	8.2	0	0	0
Fosinopril Sodium	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	18	397%	12	Amidation, Bromination, Butyllithium, C=C Hydrogenation, Carbonate Synthesis, Carbonyl Reduction, Catalytic Hydrogenation, Decarboxylation, Dehydration, Enzymatic Resolution (Biotechnology), Ester Hydrolysis, Formylation, Grignard Coupling, Grignard Reacti	2009	--	33.5	3.32	0.16
Montelukast	Anti-histamine	Allergic Rhinitis, Bronchial Asthma, Perennial Allergic Rhinitis, Exercise-Induced Bronchoconstriction , Allergic Rhinitis, Asthma	Chemical Pharmaceuticals	68	228%	28	Amination, Bromination, Friedel-Crafts Reaction, N-Methylation	--	3.4	97.5	0.62	0.11
Macitentan	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	21	41%	15	Bromination, Chlorination, Cyanation, Esterification, Methoxycarbonylation, N-Arylation, O-Arylation, Pyrimidine Synthesis	2025	--	0.2	0.01	0
Pentosan Polysulfate Sodium	Pain Management	Bladder Pain Or Discomfort Associated With Interstitial Cystitis	Chemical Pharmaceuticals	23	40%	13	Oxidation, purification	2010	7.3	6.7	0.45	0
Salmeterol Xinafoate	Anti-asthmatic	Asthma, Bronchitis	Chemical Pharmaceuticals	5	83%	9	C-Oxidation, Demethylation, Friedel-Crafts Reaction, Hydroxylation, Nitration, O-Alkylation	2011	5.1	1.5	0.87	0
Montelukast Sodium	Anti-allergic	Seasonal Allergic Rhinitis, Bronchial Asthma, Perennial Allergic Rhinitis, Exercise-Induced Bronchoconstriction (Eib), Allergic Rhinitis (Ar), Asthma	Chemical Pharmaceuticals	811	33%	165	Amination, Bromination, Friedel-Crafts Reaction, N-Methylation	2012	9.8	1556.6	80.67	0.41
Reserpine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	25	266%	21	Extraction (Biotechnology)	--	--	1.5	0.09	0.01
Candesartan Cilexetil	Anti-hypertensive	Hypertension, Heart Failure, Renal Parenchymal Hypertension	Chemical Pharmaceuticals	134	116%	80	Azidation, Biosynthesis, Bromination, Carbonate Synthesis, Curtius Rearrangement, Esterification, Grignard Reaction, Hydrolysis, Iodination, Iodition, N-Alkylation, Nitro Reduction, O-Alkylation, Suzuki Coupling Reaction, Tetrazole Synthesis	2011	--	82.1	2.14	4.08
Lercanidipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	160%	2	Condensation, Formylation, Grignard Reaction, Hantzsch Pyridine Synthesis, Hydrogenation, Knoevenagel Condensation, Mannich Reaction, Nitro Reduction, Pyridine Synthesis	--	--	36.7	0	0
Lercanidipine Hydrochloride	Anti-hypertensive	Hypertension, Angina, Heart Failure	Chemical Pharmaceuticals	80	35%	18	Friedel-Crafts Reaction, Grignard Reaction, Hantzsch Pyridine Synthesis, Hydrogenation, Knoevenagel Condensation, Mannich Reaction, N-Formylation, Nitro-Reduction	2024	2.9	51.7	11.07	0.01
Metoprolol Succinate	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	76	115%	63	Butyllithium, Oxirane Amination, Oxirane Synthesis	2035	--	549.6	75.48	17.68
Syrosingopine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	1	31%	1	Phosgenation	--	2.5	--	0	0
Efonidipine Hydrochloride	Anti-hypertensive	Angina Pectoris, Hypertension	Chemical Pharmaceuticals	1	24%	1	Arbuzov Reaction, Azeotropic Distillation, Hantzsch Pyridine Synthesis, Hydroxyethylation, Knoevenagel Condensation, Transesterification	2016	--	0	0	0
Dihydroergotamine Mesylate	Pain Management	Migraine	Chemical Pharmaceuticals	18	14%	14	--	2001	6.5	0.9	0	0
Manidipine Hydrochloride	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	5	92%	7	Bromination, Hantzsch Pyridine Synthesis	2036	--	2.9	0.01	0.05
Metoprolol Tartrate	Anti-hypertensive	Heart Failure, Hypertension	Chemical Pharmaceuticals	164	44%	66	Butyllithium, Oxirane Amination, Oxirane Synthesis	1992	--	2018.9	275.79	41.27
Hyoscyamine Sulfate	Pain Management	Cramps,Irritable Bowel Syndrome, Pain	Chemical Pharmaceuticals	15	77%	5	Plant extraction, decarboxylation	--	7.4	0.1	0.01	0
Ergotamine Tartrate	Pain Management	Headache	Chemical Pharmaceuticals	8	38%	9	Enzyme culture	--	6.8	1.1	0	0.13
Indapamid Hemihydrate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	59%	1	Decarboxylation, Indoline Synthesis, Nitrozation, No Reduction	--	--	--	0	0
Coenzyme A	Vitamin	Supplement	Biotech & Biochemicals	2	11%	1	Extraction, CoA biosynthesis,decarboxylation	--	8.1	0.2	0	0.38
Coenzyme Q9	Vitamin	Supplement	Biotech & Biochemicals	3	--	2	Fermentation	--	13.8	--	0.24	12.08
Formoterol Fumarate	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	2	34%	8	--	2016	5.8	0	0	0
Formoterol Fumarate Dihydrate	Anti-asthmatic	Asthma, Chronic Obstructive Pulmonary Disease	Chemical Pharmaceuticals	38	87%	25	Bromination, Friedel-Crafts Acylation, Nitration, Nitro-Reduction, Phosgenation	--	8.1	0.6	0.21	0
Mebhydrolin Napadisylate	Anti-histamine	Allergic Rhinitis	Chemical Pharmaceuticals	1	--	2	Cyclization, decarboxylation, Recrystallisation	--	--	9	0	0
Dinalbuphine Sebacate	Pain Management	Pain	Chemical Pharmaceuticals	--	--	3	--	--	--	--	0	0
Zofenopril Calcium	Anti-hypertensive	Hypertension, Myocardial Infarction	Chemical Pharmaceuticals	8	83%	3	Diazomethane Technology, Hydrolysis	--	--	7.7	0.53	0.03
Angiotensin Acetate	Anti-hypertensive	Hypertension	Biotech & Biochemicals	1	--	--	Coupling Reaction	--	--	2.7	0	0
Cyclosporine	Anti-allergic	Dry Eye Disease	Chemical Pharmaceuticals	25	15%	32	Isolation	2009	15.0	3.2	1.45	0.17
Aliskiren Hemifumarate	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	6	151%	8	Bromination	2018	--	0	0.02	0
Cyanocobalamin	Vitamin	Vitamin B12 Deficiency, Addisonian Anemia	Chemical Pharmaceuticals	537	--	302	Esterification	2024	3.6	2161	8.31	10.82
Ziconotide	Pain Management	Pain	Chemical Pharmaceuticals	1	72%	3	Solid Phase Synthesis	2010	5.8	0	0	0
Hydrocodone	Pain Management	Acute Pain	Chemical Pharmaceuticals	--	46%	1	Isomerization, hydration, Oxidation	--	--	--	0	0
Tiprolidine Hydrochloride	Anti-histamine	Allergy, Hay Fever, And The Common Cold	Chemical Pharmaceuticals	--	136%	2	Wittig condensation, isomerisation	--	6.3	--	0	0
Piritramide	Pain Management	Colon Cancer And Minimal Residual Disease, Pain	Chemical Pharmaceuticals	--	86%	1	Bromination	--	--	--	0	0
Nicomorphine	Pain Management	Chronic Non-Malignant And Other Neuropathic Pain	Chemical Pharmaceuticals	--	106%	1	--	--	--	--	0	0
Naldemedine	Pain Management	Opioid-Induced Constipation with cancer pain	Chemical Pharmaceuticals	--	--	1	Alcohol Oxidation, Amidation, Amine Alkylation, Bromination, Esterification, Ketalization, Oxidation, Reductive Debenzylation, Strecker Synthesis	--	--	--	0	0
Fluticasone	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	49	25%	49	Chemoenzymatic asymmetric route, bioreduction of ketone, alcohol dehydrogenase	--	4.3	0	0	0
Carbonic Anhydrase	Anti-hypertensive	Glaucoma, Idiopathic Intracranial Hypertension, Altitude Sickness, Congestive Heart Failure, And Epilepsy	Biotech & Biochemicals	2	58%	--	--	--	--	--	0	0
Ceruloplasmin	Pain Management	Anti-Inflammatory, Analgesic	Biotech & Biochemicals	10	--	7	Enzymatic biotechnology	--	--	0.1	0	0
Butalbital	Pain Management	Tension, Headache, Migraine	Chemical Pharmaceuticals	--	167%	1	Biosynthesis	--	--	0	0	0.01
Fentanyl Hydrochloride	Pain Management	Severe, Chronic Pain, Cancer Realted Pain	Chemical Pharmaceuticals	--	44%	1	Recrystallisation	2012	--	--	0	0
Gabapentin Enacarbil	Pain Management	Restless Legs Syndrome (Rls) And Postherpetic Neuralgia	Chemical Pharmaceuticals	--	808%	10	Carbonate Synthesis, Condensation, Cyanation, Esterification, Iodition, Knoevenagel Condensation, Michael Addition, Wittig Reaction	2022	8.2	0.9	0.13	0
Hydrocodone Bitartrate	Pain Management	Pain	Chemical Pharmaceuticals	--	472%	2	Isomerization, hydration, Oxidation, Hydrolysis	2020	--	--	0	0
Labetalol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	--	48%	1	Acylation, Butyllithium, Friedel-Crafts Acylation, Reductive Amination	2006	--	131.3	0.01	0.51
Mepivacaine Hydrochloride	Pain Management	Anaesthetia, Pain	Chemical Pharmaceuticals	--	42%	5	Optical enantiomer, methylation	1982	6.9	0.1	0	0.07
Nedocromil Sodium	Anti-allergic	Hypersensitivity Reactions	Chemical Pharmaceuticals	--	117%	1	Amido acylation reaction, friedel-crafts acylation reaction, carbon-oxygen bond cleavage reaction, substitution reaction, catalytic hydrogenating reduction, cyclic condensation, ester hydrolysis	2012	2.7	--	0	0
Oxymorphone Hydrochloride	Pain Management	Pain	Chemical Pharmaceuticals	--	57%	3	Oxidization, hydrogenation	2013	--	--	0	0
Remifentanil Hydrochloride	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	--	127%	1	Alkylation reaction, acylation	2010	9.0	--	0	0
Sufentanil Citrate	Pain Management	Acute pain	Chemical Pharmaceuticals	--	6%	2	Aminomethano desilylation-cyclization, Swern oxidation	2027	--	--	0	0
Emedastine Difumarate	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	--	153%	1	--	2013	8.4	--	0	0
Antazoline Hydrochloride	Anti-histamine	Nasal Congestion, Eye Allergy	Chemical Pharmaceuticals	18	99%	99	--	1996	--	0	0	0
Antazoline Sulfate	Anti-allergic	Allergic Conjunctivitis	Chemical Pharmaceuticals	--	189%	6	--	--	6.9	--	0	0
Trimeperidine Hydrochloride	Pain Management	Pain, Cute Left Ventricular Failure, Pulmonary Edema, Cardiogenic Shock, Preparation For Surgery, Childbirth, High Fever	Chemical Pharmaceuticals	--	--	11	--	--	9.5	0.9	0.17	0.02
Barnidipine	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	20	17%	54	Carbonate Synthesis, Carbonyl Reduction, Chlorosulfonation, Epoxidation, Hantzsch Pyridine Synthesis, Knoevenagel Condensation, Nitro Reduction, Pyridine Synthesis	2035	--	0	0	0
Aranidipine	Anti-hypertensive	Angina Pectoris, Hypertension	Chemical Pharmaceuticals	44	47%	32	Pyridine Synthesis	--	--	--	0	0
Dilevalol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	7	73%	17	Acylation, Esterification, Friedel-Crafts Acylation	--	--	--	0	0
Nadoxolol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	40	29%	10	Kinetic resolution	--	--	--	0	0
Ramatroban	Anti-asthmatic	Asthma	Chemical Pharmaceuticals	7	360%	12	Bromination, Carbonyl-Reduction, Friedel-Crafts Reaction, Hydrogenolysis, N-Alkylation, O-Alkylation, Resolution	--	3.4	--	0.08	0
Tetryzoline	Anti-allergic	Discomfort And Redness Of The Eye, Allergy	Chemical Pharmaceuticals	17	85%	39	--	--	5.5	--	0	0
Moprolol	Anti-hypertensive	Hypertension	Chemical Pharmaceuticals	2	13%	8	Phenol etherification reaction, amination reaction	--	--	--	0	0
25-Hydroxycholecalciferol	Vitamin	Secondary Hyperparathyroidism	--	--	183%	--	Bromination, hydroxylation	2006	4.3	0	0	0
Cholecalciferol	Vitamin	Refractory Rickets, Hypoparathyroidism And Familial Hypophosphatemia	Food, Nutra & Extracts	413	70%	132	Esterification,Crystllization, Filtration, Saponification	--	7.0	1772.2	17.59	0.01
Anakinra	Anti-Gout	Rheumatoid Arthritis, Neonatal-Onset Multisystem Inflammatory Disease	--	1	76%	1	Esterification, bromination, hydrolysis	--	--	--	0	0
Dexamethasone	Anti-Gout	Arthritis	Chemical Pharmaceuticals	368	133%	126	Amidation, Gabriel Synthesis, Gabriel-Colman Rearrangement, N-Methylation, Thiazole Synthesis	2020	10.7	120.4	39.67	0.71
Arginine	Anti-hypertensive	Heart And Circulatory Diseases	--	--	160%	--	Recombinant DNA technology	--	6.7	5565.6	0.01	20.72
Arotinolol Hydrochloride	Anti-hypertensive	Hypertension	--	--	29%	--	--	--	--	--	0	0
Articaine	Pain Management	Toothache	Chemical Pharmaceuticals	--	501%	1	Amidation reaction, ammoniation reaction	--	8.5	116.3	33.21	0
Atorvastatin	Anti-hypertensive	Primary Hyperlipidemia And Mixed Dyslipidemia	Chemical Pharmaceuticals	45	13%	38	Amination, Biosynthesis, Bromination, C-Acylation, Carbonate Synthesis, Chlorosulfonation, Condensation, Cyanation, Enzymatic Reduction (Biotechnology), Enzymatic Resolution (Biotechnology), Esterification, Friedel-Crafts Acylation, Friedel-Crafts Reaction	--	3.3	20.2	22.62	1.57
Dexmedetomidine	Pain Management	Sedative, Pain, Anxiety	Chemical Pharmaceuticals	7	112%	7	Acylation, Bromination, Dehydration, Diazotization, Friedel-Crafts Acylation, Grignard Reaction, Resolution	2011	5.7	39	0	0
Doxazosin	Anti-hypertensive	Benign Prostatic Hyperplasia, Hypertension	Chemical Pharmaceuticals	1	35%	2	Butyllithium, Carbonate Synthesis, Chlorination, Cyanation, Oxidation	2012	--	15.3	0.35	0
Benzocaine	Pain Management	Topical Anesthetic In Sore Throat, Mouth Ulcers, Tooth Ache & Sore Gums	Chemical Pharmaceuticals	75	53%	49	C-Oxidation, Nitration, No-Reduction, Oxidation	--	2.7	541.9	65.98	1.56
Betamethasone Sodium Phosphate	Anti-Gout	Atopic Dermatitis, Rheumatoid Arthritis	Chemical Pharmaceuticals	1	--	2	Recombinant DNA technology	--	14.1	4.7	0	0
Botulinum Toxin A	Pain Management	Cervical Dystonia, Axillary Hyperhidrosis, Excessive Underarm Sweating, Migraine	--	--	--	--	Proteolytic Enzymatic process	--	8.9	--	0	0
Botulinum Toxin B	Pain Management	Cervical Dystonia associated pain	--	--	--	--	Proteolytic Enzymatic process	--	--	--	0	0
Bromocriptine	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes Mellitus	Chemical Pharmaceuticals	--	47%	1	Biosynthesis	--	--	0.1	0	0.03
Gabapentin	Pain Management	Epilepsy, Neuralgia, Neuropathic Pain, Postherpetic Neuralgia	Chemical Pharmaceuticals	219	41%	86	Condensation, Cyanation, Knoevenagel Condensation, Michael Addition, Nitro Reduction, Wittig Reaction, Cnitro-Reduction, Nitro-Reduction, Wittig-Horner Reaction	2017	5.5	9264.3	503.8	497.22
Bupivacaine Hydrochloride	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	68	13%	27	Bromination	2017	8.1	19.8	1.54	0.23
Calcifediol	Vitamin	Secondary Hyperparathyroidism	Food, Nutra & Extracts	11	413%	12	Biosynthesis, Bromination, Hydroxylation	2020	5.5	0	0.01	0
Hydromorphone	Pain Management	Pain	--	--	41%	--	Isomerization, oxidation	2019	--	0.2	0	0
Canagliflozin	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes	Chemical Pharmaceuticals	20	22%	24	Biosynthesis, Bromination, Carbonate Synthesis, Carbonyl Reduction, Dehydroxylation, Esterification, Friedel-Crafts Reaction, Iodination, Iodition, O-Silylation, Suzuki Coupling Reaction	2025	--	4.9	0.56	0.01
Iloprost	Anti-hypertensive	Arterial Hypertension	--	--	160%	--	Alcohol Oxidation, Baeyer-Villiger Oxidation, Bromination, Carbonate Synthesis, Carbonyl Reduction, Condensation, Cyclopropanation, Decarboxylation, Diazotization, Diels-Alder Reaction, Esterification, Hydrogenolysis, Hydrolysis, Hydroxylation, Jones Oxida	--	--	--	0	0
Chirocaine	Pain Management	Surgery And Obstetrics pain	--	--	22%	--	Bromination	--	7.3	1.1	0	0
Chloroprocaine	Pain Management	Anaesthesia, Pain	--	--	291%	--	De novo synthesis of bacteriochlorins	--	--	--	0	0
Codeine	Pain Management	Pain, Cough	--	--	66%	--	Methylation	--	5.7	106.7	0	36.33
Colchicine	Anti-Gout	Familial Mediterranean Fever, Gout	Chemical Pharmaceuticals	2	--	1	DNA Recombinanat technology	2028	9.3	11.5	0	0
Cyclobenzaprine Hydrochloride	Pain Management	Musculoskeletal Pain	Chemical Pharmaceuticals	118	64%	53	Co reduction, cyclization, friedal crafts reaction, grignard reaction, perkin condensation	2023	7.2	321.2	10.65	0.35
Dapagliflozin	Anti-hypertensive	Hpertension Associated With Diabetes	Chemical Pharmaceuticals	34	136%	31	Acyalation, carbonate synthesis, carbonyl reduction, cyanation, cyclization	2020	29.0	0.3	0.16	0.05
Dextromethorphan	Anti-allergic	Cough, Allergy	Chemical Pharmaceuticals	14	342%	11	Grewe's cyclization	--	6.2	67.9	298.34	0.08
Levobupivacaine	Pain Management	Anaesthesia, Pain, Postoperative Pain	--	--	39%	--	Oxidative de-amination and stereospecific ring closure	--	8.2	1.1	0	0
Doxycycline	Pain Management	Inflammation, Bacterial Infection, Allergy	Chemical Pharmaceuticals	16	75%	16	Esterification, Hydrogenation, Friedel-Crafts Reaction	2016	9.7	1.7	4.54	162.24
Empagliflozin	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes	Chemical Pharmaceuticals	112	467%	54	Butyllithium, Carbonate Synthesis, Carbonyl Reduction, Cyanation, Cyclization, Formylation, Friedel-Crafts Reaction, Glycosidation, Grignard Reaction, Lithiation, N-Arylation, Nitration, Nitro Reduction, O-Alkylation, O-Arylation, O-Silylation, Phosgenatio	2025	--	55.3	0.61	0.03
Omalizumab	Anti-asthmatic	Asthma, Urticaria	--	1	308%	2	Acylation, Bromination, Friedel-Crafts Acylation, Nitration, Nitro Reduction, Nitro-Reduction, Phosgenation	2025	8.1	--	0.01	0
Eprosartan	Anti-hypertensive	Hypertension	--	--	109%	--	Bromination, Chlorination, Hydrogenolysis, Hydrolysis	2024	--	150.1	36.38	0
Ergocalciferol	Vitamin	Hypoparathyroidism, Refractory Rickets, And Familial Hypophosphatemia	Food, Nutra & Extracts	59	228%	32	Esterification, Hydrolysis	--	9.7	33.2	0.41	0.4
Ertugliflozin	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes	Chemical Pharmaceuticals	1	25%	2	Aldol Addition, Cannizzaro Reaction, Hydrogenolysis, Nitration, Nitro Reduction, Oxidation, Phosgenation, Sandmeyer Reaction	2030	--	0	0	0
Etanercept	Anti-Gout	Rheumatoid Arthritis	Chemical Pharmaceuticals	5	229%	4	Bromination, Kumada-Tamao-Corriu Coupling, Nitration, Nitro Reduction, S-Alkylation, Thiophosgenation, Triazole Synthesis	--	3.8	0.3	0	0
Ethyl Chloride	Pain Management	Pain caused by injections and minor surgical procedures	--	--	45%	--	Chlorination and hydrochlorination	1970	--	2647.7	61318.27	660325.77
Etoricoxib	Anti-Gout	Osteoarthritis, Ankylosing Spondylitis (As), Acute Gouty Arthritis (Ga), Rheumatoid Arthritis	Chemical Pharmaceuticals	54	598%	29	Amidation, Chlorination, Chlorosulfonation, Dehydrogenation, Diazotization, Mesylation, Michael Addition, S-Alkylation, Sulfonamidation	--	11.6	156.9	2.82	0
Evolocumab	Anti-hypertensive	Hyperlipidemia	--	--	--	--	--	--	--	--	0	0
Ezetimibe	Anti-hypertensive	Homozygous Familial Hypercholesterolemia, Homozygous Sitosterolemia, Primary Hyperlipidemia, Mixed Hyperlipidemia	Chemical Pharmaceuticals	305	135%	74	Acylation, Butyllithium, Carbonate Synthesis, Chlorination, Formylation, Friedel-Crafts Acylation, Grignard Reaction, Hydrogenolysis, Lithiation, Pyridine Synthesis, Carbamate Synthesis, Carbonyl-Reduction, Enantioselective Carbonyl-Reduction, Friedel-Craf	2013	--	70.4	18.32	0.15
Febuxostat	Anti-Gout	Gout And Hyperuricemia, Hyperuricemia	Chemical Pharmaceuticals	107	431%	34	Fluorination, N-Arylation, O-Acetylation, O-Demethylation, S-Arylation	2014	11.4	35.2	3.74	0.04
Fenofibric Acid	Anti-hypertensive	High Cholesterol And High Triglyceride Levels	Chemical Pharmaceuticals	25	54%	38	Hydroxylation, Nitration, Oxidation, C-Oxidation, Demethylation, Friedel-Crafts Reaction, O-Alkylation	2027	--	39	2.37	1.16
Parecoxib	Pain Management	Pain	--	--	44%	--	Butyllithium, Formylation	--	--	0.1	0	0
Aliskiren	Anti-hypertensive	Hypertension	--	--	290%	--	Benzothiophene Systhesis	2029	--	0.1	0	0
Prednisolone	Anti-Gout	Arthritis, Blood Problems, Immune System Disorder, Skin And Eye Conditions, Breathing Problems, Cancer, And Severe Allergies	Chemical Pharmaceuticals	305	108%	100	Chlorination, Chlorosulfonation, Dehydration, Diazotization, Friedel-Crafts Reaction, Hydrazine Synthesis, N-Acetylation, Pyrazole Synthesis, Sulfonamidation	2018	9.5	281.6	172.69	11.65
Fimasartan	Anti-hypertensive	Hypertension	--	--	813%	--	Bromination	--	--	0.2	0	0
Fludrocortisone	Anti-hypertensive	Hypertension	--	--	50%	--	Bromination, Diels-Alder Reaction, Epoxidation, Fluorination, Hydroxylation, Mesylation	--	--	0	0	0
Fluvastatin	Anti-hypertensive	Atherosclerosis, Cardiovascular Disorder	Chemical Pharmaceuticals	17	439%	7	Aldol Addition, Amidation, Carbonate Synthesis, Condensation, Hydrolysis, Lithiation, Vilsmeier-Haack Reaction, Aldol Condensation Reaction, Carbonyl Asymmetric Reduction, Carbonyl-Reduction, Ester Hydrolysis, Friedel-Crafts Reaction, Low Temperature Lithi	--	--	5.8	6.58	3.13
Folic Acid	Vitamin	Folic Acid Deficiency, Megaloblastic Anemia, Anemias Of Nutritional Origins, Pregnancy, Infancy, Or Childhood	Chemical Pharmaceuticals	275	104%	172	Acylation, Amine Alkylation, Aminoacid Coupling, Bromination, Carbonate Synthesis, Carboxylation, Hydrolysis, N-Acylation, N-Alkylation, Nitration, Nitro Reduction, Pteridine Synthesis, Pyrimidine Synthesis	--	4.0	722.6	169.28	57.65
Pregabalin	Pain Management	Diabetic Peripheral Neuropathic Pain	Chemical Pharmaceuticals	789	30%	235	Amine Alkylation, Asymmetric Hydrogenation, Azide Reduction, Azide Synthesis, Baylis-Hillman Reaction, Bromination, C-Alkylation, Carbonate Formation, Carbonyl Reduction, Chromatography, Hofmann Degradation, Hydrolysis, Nitrile Reduction	2013	3.7	2574.5	278.19	7.27
Fospropofol	Pain Management	Anesthesia Care Sedation, Pain	--	--	102%	--	Chlorination, Hydrogenolysis	--	6.6	0	0	0
Glibenclamide	Anti-hypertensive	Hypertension Associated With Type 2 Diabetes Mellitus	--	--	175%	--	Acylation reaction, chlorosulfonation reaction	--	--	65.5	36.73	0.23
Glucosamine Sulfate	Anti-Gout	Osteoarthritis	Chemical Pharmaceuticals	3	197%	6	Amidation, Arbuzov Reaction, Bromination, Dehydration, Diazotization, Fermentation, Fischer Indole Synthesis	--	4.0	2204.6	0	0.13
Propofol	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	64	211%	44	Isopropylation	2015	9.4	486.4	0.19	8.92
Hyaluronic Acid	Anti-Gout	Painand inflammation associated with rheumatoid and osteoarthritis and low backpain	Fine & Speciality Chemicals	77	484%	34	Friedel-Crafts Reaction	2003	7.2	1000.2	11.72	0.54
Hyaluronidase	Pain Management	off-labelin chronicpainmanagement in edema	Chemical Pharmaceuticals	13	28%	14	Streptomyces koganeiensis culture process	2028	8.6	0	0	0
Ropivacaine	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	8	41%	9	Amidation, Amine Alkylation, Chlorination, N-Alkylation, Resolution	2026	8.3	0.1	0.01	0
Hydroxocobalamin	Vitamin	Cyanide Poisoning, Pernicious Anaemia,	Chemical Pharmaceuticals	19	57%	21	Alcohol Oxidation, Fermentation, Hydrogenation, Oxidation, Fermentation (Biotechnology)	2012	3.6	0.1	0	0
Hydroxyzine	Anti-histamine	Histamine-mediated pruritus and pruritus due to allergic conditions such as chronic urticaria	Chemical Pharmaceuticals	6	8%	3	Acylation, Chlorination, Dehydroxy-Chlorination, Friedel-Crafts Acylation, N-Dehydroxy-Chlorination	2002	--	2.2	27.94	7.8
Hyoscine Butyl Bromide	Pain Management	Diverticula Pain	Chemical Pharmaceuticals	288	24%	67	Biosynthesis, Friedel-Crafts Acylation, N-Dehydroxy-Chlorination	--	4.3	170.8	11.52	1.17
Venlafaxine	Pain Management	Anxiety, Major Depressive Disorder, Chronic Pain	Chemical Pharmaceuticals	17	512%	18	Eschweiler-Clarke Reaction	2022	9.9	408.8	231.54	1.05
Infliximab	Anti-Gout	CrohnS Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis	Chemical Pharmaceuticals	65	573%	36	Ethoxymethylation, Isoxazole Synthesis	--	--	--	3.15	0.18
Klorzoxazon	Pain Management	Muscle Spasm	--	--	53%	--	Nitration, NO2 reduction, phosgenation	--	7.7	349.4	0	0
L-Arginine	Anti-hypertensive	Congestive Heart Failure (Chf), Chest Pain, High Blood Pressure, And Coronary Artery Disease	Fine & Speciality Chemicals	115	160%	112	Fermentation	--	6.7	6770.2	16.56	868.65
Lesinurad	Anti-Gout	Gout, Hyperuricemia	Chemical Pharmaceuticals	233	6%	81	Cyclization process, Distillation, Centrifugation,purification	2025	10.8	0.1	167.38	51.48
Levamlodipine Besylate	Anti-hypertensive	Angina Pectoris; Hypertension	--	--	--	--	--	--	--	--	0	0
Liraglutide	Anti-hypertensive	Hpertension Associated With Diabetes	Chemical Pharmaceuticals	15	681%	13	Fermentation, Fermentation (Biotechnology), Solid Phase Synthesis, Urea Synthesis	2036	--	0	0	0.02
Loteprednol Etabonate	Pain Management	Post-operative inflammation andpainfollowing ocular surgery	Chemical Pharmaceuticals	38	47%	18	Purification method, crystallization	2012	7.4	0.5	0.07	0.01
Lumiracoxib	Anti-Gout	Acute Pain, Dysmenorrhoea; Gout, Osteoarthritis	--	2	46%	1	Amination, Fischer Indole Synthesis, Friedel-Crafts Acylation	--	--	--	0	0.02
Magnesium Sulfate	Pain Management	Pain	Chemical Pharmaceuticals	530	69%	397	Evaporation method	--	4.9	59346.4	0.01	0.03
Manidipine	Anti-hypertensive	Hypertension	--	--	46%	--	Bromination, Hantzsch Pyridine Synthesis, Pyridine Synthesis	2029	--	2	0	0
Meperidine	Pain Management	Pain	--	--	81%	--	Alkylation	--	4.2	4.1	0	0
Mepivacaine	Pain Management	Diabetic Neuropathies; Neuropathic Pain; Postherpetic Neuralgia	--	--	32%	--	Optical enantiomer, methylation	--	--	0.1	0	0
Methotrexate	Anti-Gout	Active Polyarticular-Course Juvenile Rheumatoid Arthritis	Chemical Pharmaceuticals	210	153%	75	Isolation	2020	2.7	7.6	0.86	0.03
Methoxyflurane	Pain Management	Short-term relief of moderate to severe acutepainin adult trauma patients	--	--	279%	--	Dehydrochlorination	1999	3.3	--	0	0
Amiloride	Anti-hypertensive	Hypertension	Fine & Speciality Chemicals	1	731%	1	Reduction, Methylation, Chlorination, Condensation	2018	--	12.7	0.51	0
Acetazolamide	Anti-hypertensive	Glaucoma, Idiopathic Intracranial Hypertension, Congestive Heart Failure, Altitude Sickness, Periodic Paralysis, And Epilepsy	Chemical Pharmaceuticals	100	45%	33	Catalytic Hydrogenation, Chlorination, Oxidation, S-Oxidation, Sulfonamidation	--	4.6	454.8	59.47	5.99
Methylcobalamin	Vitamin	Anaemia; Vitamin Deficiency	--	--	61%	--	Reduction, methylation	2021	7.2	21.8	1.34	0.4
Midazolam	Pain Management	Sedative, Pain, Anxiety	Chemical Pharmaceuticals	84	59%	32	Amidine Synthesis, Cyclization, Friedel-Crafts Reaction, Halex Reaction, Imine Synthesis, Michael Addition, Nitroolefine-Reduction, N-Nitrosation, Schiemann Reaction	2028	7.6	137.7	0.97	0.01
Milnacipran	Pain Management	Depression, Fibromyalgia	Chemical Pharmaceuticals	1	175%	3	Amidation, Bromination, Butyllithium, Dehydroxy-Amidation, Delepine Amination, Phthalimide Deprotection	--	6.6	0.1	0.58	0.14
Naloxegol	Pain Management	Opioid-induced constipation (OIC) in adult patients with chronic non?cancerpain	--	--	132%	--	Alcohol Oxidation, Amine Alkylation, Bromination, Carbonyl Reduction, Catalytic Hydrogenation, Oxidation	--	--	0.2	0	0
Naloxone	Pain Management	Diagnosis Of Suspected Acute Opioid Overdose, Moderate Pain	Chemical Pharmaceuticals	9	96%	3	Amine Alkylation, Carbonyl Reduction, N-Methylation	--	11.4	0	0	0.05
Naltrexone	Pain Management	Alcohol Dependence, Pain	Chemical Pharmaceuticals	20	6%	13	Bromination	2020	8.8	0.3	0.43	1.22
Nicotinamide	Vitamin	Acne Vulgaris	--	--	157%	--	ketalization,phosphorylation, Ammination	--	4.9	3057	1834.18	22.26
Nitroglycerin	Anti-hypertensive	Angina Or Chest Pain Due To Cardiovascular Disease, As Well As To Treat Peri-Operative Hypertension Or Induce Intra-Operative Hypotension	--	--	57%	--	Reduction	2029	--	82	25.93	0.22
Adalimumab	Anti-Gout	Ankylosing Spondylitis, Adult CrohnS Disease, Juvenile Idiopathic Arthritis, Pediatric CrohnS Disease, Plaque Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis	Chemical Pharmaceuticals	2	128%	3	Methylation	2032	6.5	0	0.43	0.03
Oxymorphone	Pain Management	Cancer Pain; Musculoskeletal Pain	--	--	57%	--	Oxidization, hydrogenation	--	4.6	8	0.02	1.69
Phylloquinone	Vitamin	Haemorrhagic Conditions, Antidote For Coumarin Anticoagulants In Hypoprothrombinaemia	--	42	80%	41	Plant extraction	--	6.8	130.5	0	0
Pioglitazone	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes	Chemical Pharmaceuticals	28	65%	9	Bromination, C=C Hydrogenation, Hydroxymethylation, Meerwein Arylation, No-Reduction, O-Alkylation, O-Arylation, Carbonyl Reduction, N-Arylation	2021	--	18.6	29.88	0.05
Pitavastatin	Anti-hypertensive	Hyperlipidemia, Hpertension Associated With Diabetes Mellitus, Clinical Atherosclerosis	Pharma Intermediates	2	69%	1	Alcohol Oxidation, Carbonyl Oxidation, Carbonyl Reduction, Chlorination, Condensation, Coupling Reaction, C-Oxidation, Deshydratation, Fermentation, Fermentation (Biotechnology), Friedel-Crafts Reaction, Knoevenagel Condensation, Lactonization, No-Reductio	2030	--	0	0	0
Pitavastatin Calcium	Anti-hypertensive	Dyslipidaemias, Hypercholesterolaemia, Hyperlipidaemia	Pharma Intermediates	35	181%	32	Carbonyl Oxidation, Carbonyl Reduction, Chlorination, Coupling Reaction, C-Oxidation, Deshydratation, Fermentation (Biotechnology), Friedel-Crafts Reaction, Knoevenagel Condensation, Lactonization, No-Reduction, N-Sulfonation, Quinoline Synthesis, Reformat	2015	--	1.5	0.33	0.02
Poprostenol Sodium	Anti-hypertensive	Hypertension	--	--	78%	--	Hydrolysis, cyclisation, hydrogen iodide elimination,	--	--	0.1	0.03	0
Remifentanil	Pain Management	Anaesthesia, Pain	--	--	106%	--	Acylation, Amine Alkylation, Hydrogenolysis, Strecker Synthesis	2025	5.7	0	0	0
Rocuronium	Pain Management	Muscle Fasciculation Caused By Succinylcholine, Anesthesia, pain	--	--	140%	--	Bromination	2025	8.0	1.6	0	0.27
Ropivacaine Hydrochloride	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	42	252%	29	Amidation, Chlorination, N-Alkylation, Resolution	2010	7.4	4.6	0.83	0.1
Rosiglitazone	Anti-hypertensive	Hpertension Associated With Type 2 Diabetes Mellitus	Chemical Pharmaceuticals	2	88%	2	Carbonyl Reduction, Condensation, Knoevenagel Condensation, N-Arylation	2023	--	0	0	0
Rosuvastatin	Anti-hypertensive	Hypercholesterolemia, Mixed Dyslipidemia, Heterozygous Familial Hypercholesterolemia, Hyperlipidemia, Dyslipidemia, Hypertriglyceridemia, Dysbetalipoproteinemia, Familial Hypercholesterolemia, Waldenstrms Macroglobulinemia	Chemical Pharmaceuticals	78	106%	49	Alcohol Oxidation, Amination, Butyllithium, Carbamatation, Carbonylation, Carbonyl Oxidation, Carbonyl Reduction, Condensation, Diastereoselective Carbonyl-Reduction, Esterification, Formylation, Hydrogenolysis, Hydrolysis, Knoevenagel Condensation, Mesyla	2025	3.8	26.1	64.2	4.09
Adrenaline	Anti-allergic	Allergic Reactions	--	--	178%	--	Asymmetric hydrogenation, precipitation	2019	10.7	0.2	0	0
Sevoflurane	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	9	126%	11	Fluoroalkylation	2017	5.4	253	0	40.3
Simvastatin	Anti-hypertensive	Hpertension Associated With Diabeties Cardiomyopathy	Chemical Pharmaceuticals	259	10%	112	Amidation, Amination, C-Methylation, Esterification, Fermentation, Fermentation (Biotechnology), Hydrolysis, N-Methylation, O-Silylation	2027	--	724.8	59.92	27.01
Aspirin	Pain Management	Pain, Fever, Inflammation, Myocardial Infarction, Prevention Of Thromboembolism	Chemical Pharmaceuticals	168	521%	107	Kolbe-Schmitt Reaction, O-Acetylation	2021	2.5	23433.6	663.29	89.99
Sufentanil	Pain Management	Acute Pain	--	--	87%	--	Aminomethano desilylation-cyclization, Swern oxidation	--	--	--	0	0
Tetracaine	Pain Management	Short- Acting Topical Ophthalmic Anesthetic	Chemical Pharmaceuticals	8	162%	9	Bromination	1983	7.3	0.4	3.82	0.17
Theramine	Pain Management	Pain	--	--	--	--	--	--	--	--	0	43.52
Timolol	Anti-hypertensive	Glaucoma And Hypertension	Chemical Pharmaceuticals	3	268%	1	Cyclization	2010	--	5.7	0.18	0
Tinoridine Hydrochloride	Pain Management	Pain	--	--	--	--	--	--	--	--	0	0
Torasemide	Anti-hypertensive	Hypertension, Edema	--	--	112%	--	Precipitation, acidification	--	--	0.5	0.04	0.02
Alfentanil Hydrochloride	Pain Management	Pain	Chemical Pharmaceuticals	--	33%	1	Hydrolysis	1999	--	--	0	0
Triamcinolone	Anti-Gout	Osteoarthritis pain	Chemical Pharmaceuticals	--	58%	--	Coupling Reaction, N-acylation, Friedel Crafts alkylation, hydrolysis	--	8.0	0.6	0	0
Trimethoprim	Vitamin	Urinay Tract Infection	Chemical Pharmaceuticals	255	62%	112	Bromination	--	7.7	3066.7	528.5	72.76
Valsartan Hydrochlorothiazide	Anti-hypertensive	Hypertension	--	--	91%	--	Amidation, azidation, bromination, Carbonate Synthesis, Grignard Reaction	--	--	--	0.19	75.51
Betamethasone	Anti-Gout	Atopic Dermatitis, Rheumatoid Arthritis	Chemical Pharmaceuticals	132	21%	88	Amidation, Gabriel Synthesis, Gabriel-Colman Rearrangement, N-Methylation, Thiazole Synthesis	1986	15.3	122.3	28.85	0.27
Allisartan Isoproxil	Anti-hypertensive	Hypertension	--	--	53%	--	Suzuki Coupling Reaction	--	--	--	0	0
Allopurinol	Anti-Gout	Gout	Chemical Pharmaceuticals	1	106%	2	cycloaddition of alkyne	1988	15.9	8184.6	0	0
Alpha-Tocopherol	Vitamin	Vitamin E Deficiency	--	--	12%	--	Catalyzed condensation	--	5.4	4019	46.89	7.82
Ambroxol	Anti-asthmatic	Emphysema With Bronchitis Pneumoconiosis, Bronchitis With Bronchospasm Asthma	Chemical Pharmaceuticals	7	326%	15	Bromination, Esterification, Fermentation, Fermentation (Biotechnology), Friedel-Crafts Reaction, Grignard Reaction, N-Alkylation	--	6.5	9.9	0	0
Amitriptyline	Pain Management	Depressive Disorder, Neuropathic Pain, Migraine	Chemical Pharmaceuticals	12	58%	10	Amination, Bromination, Claisen Condensation, Friedel-Crafts Acylation, Grignard Reaction	1998	5.3	144.6	28.86	0.01
Bupivacaine	Pain Management	Dental Pain, Inflammatory Pain	--	--	92%	--	Biosynthesis	2021	6.6	3.2	0.14	0.01
Buprenorphine	Pain Management	Pain	Chemical Pharmaceuticals	9	37%	35	Brcn N-Dealkylation, Chlorosulfonation, Diazotization, Diels-Alder Reaction, Grignard Reaction, Hydrogenation	2031	14.5	0.5	0.06	0.01
Dimenhydrinate	Anti-histamine	Nausea, Vomiting, And Dizziness Caused By Motion Sickness	--	--	33%	--	Reflux dehydration	--	--	159.3	24.9	0.34
Morphine Hydrochloride	Pain Management	Addiction Disorder And Drug Abuse, Pain	Chemical Pharmaceuticals	--	114%	--	Gates synthesis, Rice synthesis	2016	--	0	0	0
Omega-3-Fatty Acid Ethyl Ester	Anti-hypertensive	Hypertension	--	--	49%	--	Transesterification reaction	--	--	49.5	0	0
Hydralazine	Anti-hypertensive	Hypertension In Pregnancy	--	--	265%	--	Oxidative chlorination, hydrolysis	--	--	42	0.35	0
Verapamil	Anti-hypertensive	Hypertension	--	--	275%	--	Bromination, Carbonyl reduction, Hoesh reduction	--	--	20.9	68.27	4.19
Amitriptyline Hydrochloride	Pain Management	Depressive Disorder, Neuropathic Pain, Migraine	Chemical Pharmaceuticals	--	69%	--	Amination, bromination, friedel-Crafts acylation	1986	6.3	525.7	76.99	0.65
Azelastine	Anti-histamine	Runny Nose, Itching, Sneezing	--	--	93%	--	Decarboxylation, Friedel-Crafts Reaction	--	--	0.4	0	0.01
Atorvastatin Calcium	Anti-hypertensive	Hyperlipidemia, Hypertension	--	--	51%	--	Amination, bromination, c-acylation, carbonate synthesis	2009	--	1425.3	355.06	21.67
Pegloticase	Anti-Gout	Gout	--	4	510%	5	N-Arylation	--	--	--	0.03	0
Epinephrine	Anti-allergic	Allergic Reactions	--	--	20%	--	Methylation	2024	9.8	0.2	0	0
Flunarizine	Pain Management	Dizziness, Vertigo And Prevention Of Migraine	--	--	110%	--	Friedal crafts reaction	--	6.6	0.3	0.31	0.05
Prilocaine	Pain Management	Pain	--	--	337%	--	Mono-nitration, catalytic hydrogenation, isolation, purification, bromination	--	6.5	52.2	7.38	0.07
Certolizumab	Anti-Gout	Psoriatic Arthritis, Ankylosing Spondylitis	--	25	75%	16	Water-phase synthetic method, diazotization reaction, sulfonyl chlorinazation	--	--	--	6.36	7.24
Diphenhydride Hydrochloride	Anti-histamine	Allergy, Hay Fever, And The Common Cold	Chemical Pharmaceuticals	310	49%	115	End-to-end continuous flow synthesis and purification	1992	7.0	122.5	0	0
Dextromethorphan Hydrobromide	Anti-allergic	Cough, Itching, Runny Nose	Chemical Pharmaceuticals	667	27%	100	Grewe cyclization	1978	6.5	78.7	76.22	0.16
Esketamine Hydrochloride	Pain Management	Anaesthesia, Pain	Chemical Pharmaceuticals	--	46%	0	Noyori catalytic asymmetric hydrogenation, sigmatropic rearrangement	1990	3.4	0	0	0
Riboflavin 5 - Phosphate Sodium	Vitamin	Dietary Supplements	Pharma Intermediates	284	193%	96	Hydrolysis	1973	5.6	25.4	68.38	0.15
Hydroxocobalamin Acetate	Vitamin	Pernicious Anemia	Chemical Pharmaceuticals	37	103%	27	Fermentation, Hydrogenation,	2026	5.8	1.2	0.01	0
Hydroxocobalamin Sulphate	Vitamin	Dietary Supplements	Chemical Pharmaceuticals	--	38%	0	Fermentation, Hydrogenation	--	3.2	--	0.01	0
Hydroxocobalamin Hydrochloride	Vitamin	Vitamin B12 Deficiency	Chemical Pharmaceuticals	19	41%	21	Fermentation, Hydrogenation, oxidation	2011	2.0	0	0.01	0
Levocetrizine	Anti-histamine	Runny Nose; Sneezing; And Redness, Itching, And Tearing Of The Eyes	Chemical Pharmaceuticals	17	162%	8	Hydrolysis	2037	4.0	0.8	0.59	0
Dexchlorpheniramine Maleate	Anti-histamine	Allergy, Hay Fever, And The Common Cold	Chemical Pharmaceuticals	92	304%	29	--	1978	--	17.5	7.55	0
Cetirizine DiHydrochloride	Anti-allergic	Hay fever And Allergic Conditions	Chemical Pharmaceuticals	662	68%	194	Chlorination, condensation, acidification	--	7.2	34.9	79.83	0.22
Diphenhydramine Citrate	Anti-Allergic	Allergy, Hay Fever, And The Common Cold	Chemical Pharmaceuticals	5	71%	10	Bromination	1966	7.2	0.2	0.03	0
Diphenhydramine Methyl Sulphate	Anti-Allergic	Sneezing, Runny Nose	Chemical Pharmaceuticals	--	39%	--	Bromination, Condensation	--	6.5	--	0	0

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